Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels.
While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions.
Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.
Table of Contents
The TRPC Family of Ion Channels: Relation to the TRP Superfamily and Role in Receptor- and Store-Operated Calcium Entry; Joel Abramowitz, Eda Yildirim, and Lutz Birnbaumer
Multiple Mechanisms of TRPC Activation; James W Putney, Jr.
TRPC2 and the Molecular Biology of Pheromone Detection in Mammals; Emily R Liman and Catherine Dulac
TRP Channels and Axon Pathfinding; Kai Cui and Xiao-bing Yuan
TRPV1 Receptors and Signal Transduction; Tamara Rosenbaum and Sidney A Simon
Complex Regulation of TRPV1 by Vanilloids; Arpad Szallasi and Peter M Blumberg
TRPV2: A Calcium-Permeable Cation Channel Regulated by Insulin-Like Growth Factors; Itaru Kojima and Masahiro Nagasawa
Molecular Mechanisms of TRPV4 Gating; Stefan Heller and Roger G O'Neil
TRPV4: A Multifunctional Nonselective Cation Channel with Complex Regulation; Tim D Plant and Rainer Strotmann
TRPV4 and TRPM3 as Volume-Regulated Cation Channels; Christian Harteneck and Günter Schultz
TRPA1: A Sensory Channel of Many Talents; Marilia Z P Guimaraes and Sven-Eric Jordt
TRPA1 in Auditory and Nociceptive Organs; Jaime García-Añoveros and Anne Duggan
TRPM8: The Cold and Menthol Receptor; David D McKemy
Activation Mechanisms and Functional Roles of TRPP2 Cation Channels; Aurélie Giamarchi and Patrick Delmas
The Ca 2+-Activated TRP Channels: TRPM4 and TRPM5; Emily R Liman
Genetics Can Be Painless: Molecular Genetic Analysis of Nociception in Drosophila; W Daniel Tracey, Jr.
TRPV Family Ion Channels and Other Molecular Components Required for Hearing and Proprioception in Drosophila; Changsoo Kim
The TRPV Channel in C elegans Serotonergic Neurons; Ji Ying Sze
TRP Channel Functioning in Mating and Fertilization; X Z Shawn Xu and Maureen M Barr
The Role of TRP Channels in Thermosensation; Makoto Tominaga
Voltage and Temperature Gating of ThermoTRP Channels; Ramon Latorre, Guillermo Vargas, Gerardo Orta, and Sebastian Brauchi
TRPV Channels' Function in Osmo- and Mechanotransduction; Wolfgang B Liedtke
TRP Channel Trafficking; Rosa Planells-Cases and Antonio Ferrer-Montiel
Protein-Protein Interactions in TRPC Channel Complexes; Petra Eder, Rainer Schindl, Christoph Romanin, and Klaus Groschner
Structural Insights into the Function of TRP Channels; Rachelle Gaudet
Functional Significance of Transient Receptor Potential Channels in Vascular Function; Scott Earley, Stacey Reading, and Joseph E Brayden
Role of TRPV4 in the Mechanotransduction of Shear Stress in Endothelial Cells; Ralf Köhler and Joachim Hoyer
A New Insight into the Function of TRPV2 in Circulatory Organs; Katsuhiko Muraki, Munekazu Shigekawa, and Yuji Imaizumi
The Role of TRPV4 in the Kidney; David M Cohen
The TRPV4 Channel in Ciliated Epithelia; Yaniré N Andrade, Jacqueline Fernandes, Ivan M Lorenzo, Maite Arniges, and Miguel A Valverde
Protease-Activated Receptors: Mechanisms by Which Proteases Sensitize TRPV Channels
to Induce Neurogenic Inflammation and Pain; Andrew Grant, Silvia Amadesi, and Nigel W Bunnett
This volume presents the most advanced compilation of work in this area to date.
– In Anticancer Research, July/ August 2008, Vol. 28, No. 4A