TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades: 1st Edition (Hardback) book cover

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

1st Edition

Edited by Wolfgang B. Liedtke, MD, PH.D.

CRC Press

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Hardback: 9780849340482
pub: 2006-09-29
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pub: 2006-09-29
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Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels.

While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions.

Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.


This volume presents the most advanced compilation of work in this area to date.

– In Anticancer Research, July/ August 2008, Vol. 28, No. 4A

Table of Contents

The TRPC Family of Ion Channels: Relation to the TRP Superfamily and Role in Receptor- and Store-Operated Calcium Entry; Joel Abramowitz, Eda Yildirim, and Lutz Birnbaumer

Multiple Mechanisms of TRPC Activation; James W Putney, Jr.

TRPC2 and the Molecular Biology of Pheromone Detection in Mammals; Emily R Liman and Catherine Dulac

TRP Channels and Axon Pathfinding; Kai Cui and Xiao-bing Yuan

TRPV1 Receptors and Signal Transduction; Tamara Rosenbaum and Sidney A Simon

Complex Regulation of TRPV1 by Vanilloids; Arpad Szallasi and Peter M Blumberg

TRPV2: A Calcium-Permeable Cation Channel Regulated by Insulin-Like Growth Factors; Itaru Kojima and Masahiro Nagasawa

Molecular Mechanisms of TRPV4 Gating; Stefan Heller and Roger G O'Neil

TRPV4: A Multifunctional Nonselective Cation Channel with Complex Regulation; Tim D Plant and Rainer Strotmann

TRPV4 and TRPM3 as Volume-Regulated Cation Channels; Christian Harteneck and Günter Schultz

TRPA1: A Sensory Channel of Many Talents; Marilia Z P Guimaraes and Sven-Eric Jordt

TRPA1 in Auditory and Nociceptive Organs; Jaime García-Añoveros and Anne Duggan

TRPM8: The Cold and Menthol Receptor; David D McKemy

Activation Mechanisms and Functional Roles of TRPP2 Cation Channels; Aurélie Giamarchi and Patrick Delmas

The Ca 2+-Activated TRP Channels: TRPM4 and TRPM5; Emily R Liman

Genetics Can Be Painless: Molecular Genetic Analysis of Nociception in Drosophila; W Daniel Tracey, Jr.

TRPV Family Ion Channels and Other Molecular Components Required for Hearing and Proprioception in Drosophila; Changsoo Kim

The TRPV Channel in C elegans Serotonergic Neurons; Ji Ying Sze

TRP Channel Functioning in Mating and Fertilization; X Z Shawn Xu and Maureen M Barr

The Role of TRP Channels in Thermosensation; Makoto Tominaga

Voltage and Temperature Gating of ThermoTRP Channels; Ramon Latorre, Guillermo Vargas, Gerardo Orta, and Sebastian Brauchi

TRPV Channels' Function in Osmo- and Mechanotransduction; Wolfgang B Liedtke

TRP Channel Trafficking; Rosa Planells-Cases and Antonio Ferrer-Montiel

Protein-Protein Interactions in TRPC Channel Complexes; Petra Eder, Rainer Schindl, Christoph Romanin, and Klaus Groschner

Structural Insights into the Function of TRP Channels; Rachelle Gaudet

Functional Significance of Transient Receptor Potential Channels in Vascular Function; Scott Earley, Stacey Reading, and Joseph E Brayden

Role of TRPV4 in the Mechanotransduction of Shear Stress in Endothelial Cells; Ralf Köhler and Joachim Hoyer

A New Insight into the Function of TRPV2 in Circulatory Organs; Katsuhiko Muraki, Munekazu Shigekawa, and Yuji Imaizumi

The Role of TRPV4 in the Kidney; David M Cohen

The TRPV4 Channel in Ciliated Epithelia; Yaniré N Andrade, Jacqueline Fernandes, Ivan M Lorenzo, Maite Arniges, and Miguel A Valverde

Protease-Activated Receptors: Mechanisms by Which Proteases Sensitize TRPV Channels

to Induce Neurogenic Inflammation and Pain; Andrew Grant, Silvia Amadesi, and Nigel W Bunnett


About the Series

Frontiers in Neuroscience

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Pharmacology
SCIENCE / Life Sciences / Neuroscience