This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
VOLUME II: Kidney as a Target Organ for Toxicity. Cardiac Toxic-ity. Lung as a Target Organ for Toxicity. Target Organ Toxic-ity: Male Reproductive System. Toxic Effects of the Female Repro-ductive System. Eye. Inner Ear. Endocrine Pancreas as a Target Organ for Toxicity. Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction. Organ Specificity in Tumor Initia-tion and Complete Carcinogenesis (including Species Variation). Index.