1st Edition

Targeted Delivery of Small and Macromolecular Drugs

Edited By Ajit S. Narang, Ram I. Mahato Copyright 2010
    630 Pages 185 B/W Illustrations
    by CRC Press

    630 Pages 185 B/W Illustrations
    by CRC Press

    Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice.

    Focusing on the delivery technologies that utilize both systemic and local routes of administration, Targeted Delivery of Small and Macromolecular Drugs brings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges.

    The contributors discuss the most promising strategies for drug targeting and also examine targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including:

      • Active targeting
      • Nucleic acid delivery and targeting
      • Intracellular/organelle-specific strategies
      • Prodrug strategies
      • Organ or tissue-specific drug delivery
      • Drug-polymer conjugates and micelles
      • Stimuli-responsive systems

    The book demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.

    Therapeutic Potential of Targeted Drug Delivery
    Ajit S. Narang and Ram I. Mahato

    Antibody Therapies for Liver Malignancy and Transplantation
    John M. Luk and Kwong-Fai Wong
    Transferrin Receptor–Mediated Transcytosis in Intestinal Epithelial Cells for Gastrointestinal Absorption of Protein Drugs
    Nurmamet Amet, Xiaoying Chen, Hsin-Fang Lee, Jennica Zaro, and Wei-Chiang Shen
    Ionizing Radiation for Tumor-Targeted Drug Delivery
    Roberto Diaz, Li Zhou, and Dennis E. Hallahan

    Recent Advances in Gene Expression and Delivery Systems
    Ravikiran Panakanti and Ram I. Mahato
    Cellular Barriers for Nucleic Acid Delivery and Targeting
    Arto Urtti
    Targeted Delivery Systems of Nonviral Nucleic Acid–Based Therapeutics
    Ga Yong Shim, Eun-Joong Kim, Rae Sung Chang, Han Young Lee, and Yu-Kyoung Oh
    Delivery and Targeting of Oligonucleotides and siRNA
    Ningning Yang and Ram I. Mahato
    Liposomes for Nonviral Gene Delivery
    Jiasheng Tu, Yan Shen, Hui Pang, and Yubing Yu

    Delivering the Bullet to the Right Intracellular Target: A Cellular Perspective on Drug Delivery
    Maria Teresa Tarragó-Trani and Brian Storrie
    Mitochondria-Targeted Drug Delivery
    Volkmar Weissig and Gerard G. M. D’Souza

    Site-Specific Prodrug Activation Strategies for Targeted Drug Action
    Mark D. Erion
    Enzyme-Activated Prodrug Strategies for Targeted Drug Action
    Jarkko Rautio, Krista Laine, Lanyan Fang, Bing Han, Kristiina Huttunen, and Duxin Sun

    Targeting Colon and Kidney: Pathophysiological Determinants of Design Strategy
    Ajit S. Narang and Ram I. Mahato
    Principles and Practice of Pulmonary Drug Delivery
    Vivek Gupta, Chandan Thomas, and Fakhrul Ahsan
    Recent Advances in Ocular Drug Delivery: Role of Transporters, Receptors, and Nanocarriers
    Gyan P. Mishra, Ripal Gaudana, Viral M. Tamboli, and Ashim K. Mitra

    Injectable Polymers for Regional Drug Delivery
    Rajendra P. Pawar, Niteen R. Shinde, Narsinha M. Andurkar, Satish A. Dake, and Abraham J. Domb
    Polymer–Drug Conjugates
    Lucienne Juillerat-Jeanneret and Feride Cengelli
    Polymer Micelles for Drug Delivery
    Sungwon Kim and Kinam Park

    Multifunctional Stimuli–Responsive Nanoparticles for Targeted Delivery of Small and Macromolecular Therapeutics
    Srinivas Ganta, Arun Iyer, and Mansoor Amiji
    Physiological Stress Responsive Gene Regulation Systems for Tissue Targeting
    Hyun Ah Kim and Minhyung Lee 


    Ajit S. Narang works for the Bristol-Myers Squibb, Co. in New Brunswick, New Jersey, in the biopharmaceutical aspects of drug delivery. He has more than eight years of experience in the pharmaceutical industry in the development of oral dosage forms and drug delivery platforms. In addition to the Bristol-Myers Squibb, Co., he has worked for Ranbaxy Research Labs (currently a subsidiary of Daiichi Sankyo, Japan) in Gurgaon, India, and Morton Grove Pharmaceuticals (currently a subsidiary of Wockhardt USA LLC, Parsippany, New Jersey) in Vernon Hills, Illinois. He has more than 35 publications and three pending patent applications, and has contributed to the development of several marketed drug products. 

    Ram I. Mahato is a full-time professor in the Department of Pharmaceutical Sciences at the University of Health Science Center, Memphis, Tennessee. He was a research assistant professor at the University of Utah, Salt Lake City; a senior scientist at GeneMedicine, Inc., The Woodland, Texas; and a postdoctoral fellow at the University of Southern California in Los Angeles, Washington University in St. Louis, and Kyoto University, Japan. He is an author or coauthor of 79 peer-reviewed articles and book chapters, and has edited/written three books. He is also a special features editor of Pharmaceutical Research and serves on the editorial boards of the Journal of Drug Targeting, Expert Opinion on Drug Delivery, and Transplantation and Risk Management. His research includes delivery and targeting of small molecules, oligonucleotides, siRNA, and genes.