1st Edition

Targeted Metallo-Drugs Design, Development, and Modes of Action

Edited By Etelka Farkas, Celine J. Marmion Copyright 2023
    390 Pages 43 Color & 53 B/W Illustrations
    by CRC Press

    390 Pages 43 Color & 53 B/W Illustrations
    by CRC Press

    Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.

    • It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy
    • It highlights recent metallo-drug developments targeting COVID-19
    • It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs

    Chapter 1 Metal-Based Prodrugs Activated by Cancer-Specific Stimuli

    Martijn Dijkstra, Hemma Schueffl, Isabella Poetsch, Petra Heffeter, and Christian R. Kowol.

    Chapter 2 Light-Activated Drugs for Photodynamic and Photoactivated Therapy

    Dmytro Havrylyuk, Austin Hachey, and Edith Glazer.

    Chapter 3 Mitochondria as a Metallo-Drug Target for Therapeutic Purposes

    Andrea Erxleben.

    Chapter 4 Transition Metal-Based Anti-Viral Agents against SARS-CoV-2 and Other Pathogenic Viruses

    Maria Gil-Moles and Ingo Ott.

    Chapter 5 Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs

    Damiano Cirri, Tiziano Marzo, Carlo Marotta, Alessandro Pratesi,, and Luigi Messori.

    Chapter 6 Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug Resistant Bacteria

    Andris Evans and Kevin Kavanagh.

    Chapter 7 Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases

    Dinorah Gambino and Lucía Otero.

    Chapter 8 Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment

    Sigridur G. Suman.

    Chapter 9 Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells

    Johannes Karges and Nils Metzler-Nolte. 

    Chapter 10 Metalloproteomics: A Powerful Technique for Metals in Medicine

    Tiffany Ka-Yan Ip, Ying Zhou, Hongyan Li, and Hongzhe Sun.

    Chapter 11 Metal-Based Nanoclusters for Biomedical Applications

    Edit Csapó.

    Chapter 12 Radiometals in Molecular Imaging and Therapy

    Izabela Cieszykowska, Wioletta Wojdowska, Dariusz Pawlak, and Renata Mikołajczak.


    Etelka Farkas, Celine J. Marmion