Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.
- It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy
- It highlights recent metallo-drug developments targeting COVID-19
- It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs
Chapter 1 Metal-Based Prodrugs Activated by Cancer-Specific Stimuli
Martijn Dijkstra, Hemma Schueffl, Isabella Poetsch, Petra Heffeter, and Christian R. Kowol.
Chapter 2 Light-Activated Drugs for Photodynamic and Photoactivated Therapy
Dmytro Havrylyuk, Austin Hachey, and Edith Glazer.
Chapter 3 Mitochondria as a Metallo-Drug Target for Therapeutic Purposes
Chapter 4 Transition Metal-Based Anti-Viral Agents against SARS-CoV-2 and Other Pathogenic Viruses
Maria Gil-Moles and Ingo Ott.
Chapter 5 Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs
Damiano Cirri, Tiziano Marzo, Carlo Marotta, Alessandro Pratesi,, and Luigi Messori.
Chapter 6 Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug Resistant Bacteria
Andris Evans and Kevin Kavanagh.
Chapter 7 Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases
Dinorah Gambino and Lucía Otero.
Chapter 8 Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment
Sigridur G. Suman.
Chapter 9 Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells
Johannes Karges and Nils Metzler-Nolte.
Chapter 10 Metalloproteomics: A Powerful Technique for Metals in Medicine
Tiffany Ka-Yan Ip, Ying Zhou, Hongyan Li, and Hongzhe Sun.
Chapter 11 Metal-Based Nanoclusters for Biomedical Applications
Chapter 12 Radiometals in Molecular Imaging and Therapy
Izabela Cieszykowska, Wioletta Wojdowska, Dariusz Pawlak, and Renata Mikołajczak.