Terahertz Biomedical Science and Technology  book cover
1st Edition

Terahertz Biomedical Science and Technology

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ISBN 9781466570443
Published June 13, 2014 by CRC Press
377 Pages 12 Color & 212 B/W Illustrations

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Book Description

A number of applications including scientific spectroscopy, security screening, and medical imaging have benefitted from the development and utilization of new and emerging terahertz (THz) generation and detection techniques. Exploring recent discoveries and the advancements of biological behaviors through THz spectroscopy and imaging and the development of THz medical techniques, Terahertz Biomedical Science and Technology contains contributions from scientists and researchers in the terahertz biomedical field and is exclusively dedicated to new and emerging terahertz biomedical research and applications.

This text offers an assessment of terahertz technology, and provides a compilation of fundamental biological studies conducted using terahertz waves. It introduces THz electromagnetic waves as a new tool for convergent studies, includes laser-based generation techniques and solid-state devices, contains a number of detectors, and discusses high-field generation methods. The material covers recent advancements in terahertz imaging for medical applications—most specifically in cancer diagnosis—reviewing the current status of the THz imaging technique for diagnosing cancers, and exploring the potential medical applications of THz radiation. It also considers the development of future medical applications using terahertz technology.

  • Summarizes the recent progress made in THz waveguides, which are absolutely essential in the development of THz endoscopes
  • Describes the dynamic imaging of drug absorption in skin, exploiting the sensitivity of THz waves to pharmaceutical materials
  • Explores the principle and applications of THz molecular imaging techniques using nanoparticle probes

Scientists and engineers involved in biological research and medical applications using optical techniques, as well as graduate students and instructors in optics, physics, electrical engineering, biology, chemistry, and medicine can benefit from this text which highlights new and emerging biomedical studies utilizing novel THz wave techniques.

Table of Contents

Introduction to Biomedical Studies Using Terahertz Waves

Joo-Hiuk Son

Section I Terahertz Technology

Terahertz Sources and Detectors

Hyunyong Choi and Joo-Hiuk Son

Tabletop High-Power Terahertz Pulse Generation Techniques

Yun-Shik Lee

Terahertz Imaging and Tomography Techniques

Hyunyong Choi and Joo-Hiuk Son

Compact Solid-State Electronic Terahertz Devices and Circuits

Jae-Sung Rieh, Daekeun Yoon, and Jongwon Yun

Waveguides for Terahertz Endoscopy

Tae-In Jeon and Daniel Grischkowsky

Section II Fundamental Biological Studies by Terahertz Waves

Terahertz Characteristics of Water and Liquids

Seung Jae Oh, Seungjoo Haam, and Jin-Suck Suh

Probing Solvation Dynamics by Terahertz Absorption Spectroscopy

Benjamin Born, Matthias Heyden, Simon Ebbinghaus, and Martina Havenith

Terahertz Spectroscopy of Biological Molecules

Seongsin Margaret Kim and Mohammad P Hokmabadi

Terahertz Spectroscopic Insight into the Structure–Function Relation in Protein Molecules

Nikolay Brandt, Andrey Chikishev, Alexey Kargovsky, and Alexander Shkurinov

Protein Dielectric Response at Terahertz Frequencies

Deepu K George and Andrea G Markelz

Nonlinear Interaction of Amino Acids and Proteins with Terahertz Waves

Gurpreet Kaur and Xi-Cheng Zhang

Biological Effects of Broadband Terahertz Pulses

Lyubov V Titova, Frank A Hegmann, and Olga Kovalchuk

Section III Terahertz Biomedical Applications

Terahertz Dynamic Imaging of Skin Drug Absorption

Kyung Won Kim, Joon Koo Han, and Joo-Hiuk Son

Terahertz for the Detection of Skin Cancer

Cecil Joseph, Shuting Fan, Emma MacPherson, and Vincent P Wallace

Application of Terahertz Technology to Breast Cancer

Maarten R Grootendorst, Massimiliano Cariati, Philip C Ashworth,

Anthony J Fitzgerald, Arnie Purushotham, and Vincent P Wallace

Frozen Terahertz Imaging of Excised Oral Cancer

Jae Yeon Park, Yookyeong Carolyn Sim, and Joo-Hiuk Son

Terahertz Molecular Imaging and Its Clinical Applications

Kwang Sung Kim, Hyuk Jae Choi, Jae Yeon Park, and Joo-Hiuk Son

Prospects in Medical Applications of Terahertz Waves and Conclusions

Joo-Hiuk Son


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Joo-Hiuk Son received his BS and MS in electronics engineering from Seoul National University, Seoul, Republic of Korea, in 1986 and 1988, respectively, and his PhD in electrical engineering from the University of Michigan, Ann Arbor, in 1994. In the early years, his research was focused on the characterization of electrical and optical properties of semiconductors and various nanosized materials. In recent years, his interest has shifted to terahertz electromagnetic interactions with biological materials and their applications in medicine. Combining his expertise on nanomaterials and terahertz medical diagnosis, he invented a highly sensitive terahertz molecular imaging technique using nanoparticle probes.


"A wonderful introduction and a lasting reference for those who wish to survey and understand the growing interest in this burgeoning technological field."
—From the Foreword by Peter H. Siegel, Senior Scientist, California Institute of Technology and NASA Jet Propulsion Laboratory