569 Pages 48 Color & 87 B/W Illustrations
    by CRC Press

    569 Pages 48 Color & 87 B/W Illustrations
    by CRC Press

    Babies of women with diabetes are nearly five times more likely to be stillborn and almost three times more likely to die in the first three months. The incidence of gestational diabetes mellitus in the U.S. is high—between 3 and 7 percent—and rising. The condition is often complicated by other risk factors such as obesity and heart disease.

    The Textbook of Diabetes and Pregnancy presents a comprehensive review of the science, clinical management, and medical implications of gestational diabetes mellitus, a condition with serious consequences that is on the increase in all developed societies. This new edition supports the latest initiatives and strategies of the International Federation of Gynecology and Obstetrics (FIGO) and adds chapters on noncommunicable diseases, obesity, bariatric surgery, and epidemiology outside Western cultures.

    Written by a cadre of experts, the book provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.

    Introduction: Merging the Legacies and Hypotheses: Maternal Medicine Meets Fetal Medicine
    Moshe Hod, Kypros Nicolaides, Hamutal Meiri, and Nicky Lieberman

    History of Diabetic Pregnancy
    David R. Hadden

    Metabolism in Normal Pregnancy
    Emilio Herrera and Henar Ortega-Senovilla

    Intermediary Metabolism in Pregnancies Complicated by Gestational Diabetes
    Bartolomé Bonet, María Bonet-Alavés, and Isabel Sánchez-Vera

    Nutrient Delivery and Metabolism in the Fetus
    William W. Hay, Jr., Paul J. Rozance, Stephanie R. Wesolowski, and Laura D. Brown

    Pathogenesis of Gestational Diabetes Mellitus
    Yariv Yogev

    Autoimmunity in Gestational Diabetes Mellitus
    Alberto de Leiva, Dídac Mauricio, and Rosa Corcoy

    Epidemiology of Gestational Diabetes Mellitus
    Yariv Yogev, Avi Ben Haroush, Moshe Hod, and Jeremy Oats

    Genetics of Diabetic Pregnancy
    Komal Bajaj and Susan J. Gross

    Animal Models in Diabetes and Pregnancy Research
    Catherine Yzydorczyk, Delphine Mitanchez, and Umberto Simeoni

    Pathologic Abnormalities of Placental Structure and Function in Diabetes
    Rhonda Bentley-Lewis, Maria Rosaria Raspollini, and Drucilla Roberts

    The Great Obstetric Syndromes: The Roots of Disease
    Rinat Gabbay-Benziv and Ahmet A. Baschat

    Placental Origins of Diabesity and the Origin of Preeclampsia
    Gernot Desoye and Berthold Huppertz

    Diagnosis of Gestational Diabetes Mellitus
    Donald R. Coustan and Boyd E. Metzger

    Cost-Effectiveness of Screening and Management Programs for Gestational Diabetes Mellitus
    Louise K. Weile, James G. Kahn, Elliot Marseille, and Nicolai Lohse

    Changing Health Policy: From Study to National Policy
    Ofra Kalter-Leibovici, Nicky Lieberman, Ronni Gamzu, and Moshe Hod

    Ideal Weight Gain in Diabetic Pregnancy
    Gerard H.A. Visser and Harold W. de Valk

    Medical Nutritional Therapy for Gestational Diabetes Mellitus
    Lois Jovanovic

    Pharmacologic Treatment of Gestational Diabetes Mellitus: When to Start and What Agent to Use
    Celeste P. Durnwald and Mark B. Landon

    Gestational Diabetes Mellitus: The Consequences of Not Treating
    Oded Langer

    Gestational Diabetes Mellitus in Multiple Pregnancies
    Matteo Andrea Bonomo and Angela Napoli

    Glycemic Goals in Diabetic Pregnancy and Defining a "Good Control": Maternal and Fetal Perspective
    Liran Hiersch and Yariv Yogev

    Insulin Therapy in Pregnancy
    Lois Jovanovic and John L. Kitzmiller

    Use of Oral Hypoglycemic Agents in Pregnancy
    Oded Langer

    The Drug Dilemma of Oral Antidiabetic Agents in Pregnancy: Metformin
    Yoel Toledano, Moshe Zloczower, and Nicky Lieberman

    Facing the Noncommunicable Diseases’ Global Epidemic: The Battle of Prevention Starts In Utero the FIGO Challenge
    Luis Cabero and Sabaratnam Arulkumaran

    Links between Maternal Health and Noncommunicable Diseases
    Anil Kapur

    Diabetic Pregnancy in the Developing World
    Eran Hadar, Eran Ashwal, and Moshe Hod

    Managing Diabetic Pregnancy in China
    Huixia Yang, Weiwei Zhu, and Rina Su

    Gestational Diabetes Mellitus, Obesity, and Pregnancy Outcomes
    Harold David McIntyre, Marloes Dekker-Nitert, Helen Lorraine Graham Barrett, and Leonie Kaye Callaway

    Obesity Versus Glycemic Control: Which Contributes More to Adverse Pregnancy Outcome?
    Amir Aviram and Yariv Yogev

    Pharmacological Treatment for the Obese Gestational Diabetes Mellitus Patient
    Fiona C. Denison and Rebecca M. Reynolds

    Role of Exercise in Reducing the Risks of Gestational Diabetes Mellitus in Obese Women
    Raul Artal

    Role of Bariatric Surgery in Obese Women Planning Pregnancy
    Ron Charach and Eyal Sheiner

    Fetal Lung Maturity
    Gian Carlo Di Renzo, Giulia Babucci, and Graziano Clerici

    Monitoring during the Later Stage of Pregnancy and during Labor: Glycemic Considerations
    Harold W. de Valk and Gerard H.A. Visser

    Timing and Mode of Delivery
    Salvatore Alberico and Gianpaolo Maso

    Management of the Macrosomic Fetus
    Federico Mecacci, Marianna Pina Rambaldi, and Giorgio Mello

    Congenital Malformations in Diabetic Pregnancy: Prevalence and Types
    Paul Merlob

    Diabetic Embryopathy in the Preimplantation Embryo
    Asher Ornoy and Noa Bischitz

    Postimplantation Diabetic Embryopathy
    Ulf J. Eriksson and Parri Wentzel

    Fetal Malformations Detected with Magnetic Resonance Imaging in the Diabetic Mother
    Tuangsit Wataganara

    Continuous Glucose Monitoring in Pregnancy
    Marlon Pragnell and Aaron Kowalski

    Insulin Infusion Pumps in Pregnancy
    Ilana Jaye Halperin and Denice S. Feig

    Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy
    Zoe A. Stewart and Helen R. Murphy

    Noninvasive Glucose Monitoring
    Itai Ben-David and Pierre Singer

    Reproduction and Its Impact on Health and Disease
    Sara Ornaghi and Michael J. Paidas

    Diabetes, Pregnancy, and the Developmental Origins of Health and Disease
    Gerard H.A. Visser and Mark A. Hanson

    Interventions to Improve Pregnancy Outcome in Obese Pregnancy: Implications for Mother and Child
    Rahat Maitland and Lucilla Poston

    Lifestyle Interventions to Reduce Risk of Diabetes among High-Risk Pregnant and Postpartum Women

    Lisa Chasan-Taber

    Can Fetal Macrosomia Be Predicted and Prevented?
    Maria Farren and Michael Turner

    Hypoglycemia in Diabetic Pregnancy
    Graziano Di Cianni, Cristina Lencioni, Emilia Lacaria, and Laura Russo

    Hypertensive Disorders and Diabetic Pregnancy
    Jacob Bar, Moshe Hod, and Michal Kovo

    Diabetic Retinopathy
    Nir Melamed and Moshe Hod

    Diabetic Nephropathy
    Elisabeth R. Mathiesen, Lene Ringholm, and Peter Damm

    Diabetic Ketoacidosis
    Annunziata Lapolla and Maria Grazia Dalfrà

    Thyroid Disease in Pregnancy
    Yoel Toledano and Gabriella Solomon

    Quality of Care for the Woman with Diabetes at Pregnancy
    Alberto de Leiva, Rosa Corcoy, Alejandra de Leiva-Pérez, and Eulàlia Brugués

    Early Pregnancy Loss and Perinatal Mortality
    Kinneret Tenenbaum-Gavish, Anat Shmuely, and Moshe Hod

    Short-Term Implications of Gestational Diabetes Mellitus: The Neonate
    Delphine Mitanchez, Catherine Yzydorczyk, and Umberto Simeoni

    Long-Term Outcomes after Gestational Diabetes Mellitus Exposure in the Offspring
    Delphine Mitanchez, Catherine Yzydorczyk, and Umberto Simeoni

    Metabolomics and Diabetic Pregnancy
    Angelica Dessì, Roberta Carboni, and Vassilios Fanos

    Fetal Growth Restriction: Evidence-Based Clinical Management
    Eduard Gratacós and Francesc Figueras


    Edited by

    Moshe Hod, MD, professor (clinical) of obstetrics and gynecology, and director, Division of Maternal Fetal Medicine, Helen Schneider Hospital for Women, Rabin Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tiqva, Israel

    Lois G. Jovanovic, MD, clinical professor of medicine, University of Southern California Keck School of Medicine, and adjunct professor of biomolecular science and engineering, University of California-Santa Barbara, and CEO and chief scientific officer, Sansum Diabetes Research Institute, Santa Barbara, USA

    Gian Carlo Di Renzo, MD, PhD, professor and chairman, Department of Obstetrics and Gynecology, and director, Centre of Perinatal and Reproductive Medicine, University Hospital, Perugia, Italy

    Alberto de Leiva, MD, PhD, Universitat Autònoma de Barcelona, Department of Endocrinology, Diabetes and Nutrition, Hospital de la Santa Creu i Sant Pau; EDUAB-HSP, CIBER-BBN,  and Fundación DIABEM, Barcelona, Spain.

    Oded Langer, MD, PhD, Babcock professor and chairman, Department of Obstetrics and Gynecology, St. Luke’s-Roosevelt Hospital Center, University Hospital for Columbia University, New York, New York, USA

    "With over 500 pages The Textbook of Diabetes and Pregnancy, now in its third edition, continues to be a comprehensive and detailed review of all aspects of management ranging from the basic science, biochemistry and physiology of pregnancy, to the principles of clinical practice. Spread over fully referenced chapters written by international experts in their field, all aspects of the Impact of diabetes on pregnancy are discussed… It is an excellent reference book and a highly authoritative tome on an increasingly common condition."
    —Dr Mark Freeman, Glycosmedia

    “The book covers everything from the physiology of diabetes in pregnancy to questions about screening and treatment. Each subject is presented as a one-sentence topic and the index is created by listing these 63 topics, which makes the book seem like a list of speakers at a seminar. The chapters do an excellent job of presenting evidence-based guidance.”
    —Anthony Shanks, MD, Indiana University School of Medicine, Doody’s Book Reviews

    Praise for previous editions:

    "… a comprehensive, thorough book devoted to one of the most common medical conditions to complicate pregnancy….No aspect of diabetes in pregnancy is left unexplored…. a very worthy purchase."
    —Gilad A. Gross, MD, Washington University School of Medicine in Doody’s Book Reviews

    "An excellent general resource ... well-suited for the trainee, particularly in obstetrics, who will care for the pregnant woman with diabetes and her offspring."
    New England Journal of Medicine

    "… an excellent resource for all clinicians caring for pregnant women with diabetes. I commend this textbook to any craving a fresh look at an old problem."