Textbook of Palliative Medicine and Supportive Care: 2nd Edition (Paperback) book cover

Textbook of Palliative Medicine and Supportive Care

2nd Edition

Edited by Eduardo Bruera, Irene Higginson, Charles F. von Gunten

CRC Press

1,322 pages

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"…the thoroughness of the text has to be admired. It is an excellent starting point for students of palliative care which makes an important contribution to any library."

British Journal of Hospital Medicine

"… covers a plethora of topics ranging from the development of palliative medicine in different countries to clinical topics and bioethics … an excellent palliative medicine resource."

—Darrell A. Owens, DNP, University of Washington Medicine in Doody’s Book Reviews

The second edition of the Textbook of Palliative Medicine and Supportive Care builds upon the strengths of the previous edition, providing an alternative approach to this ever-growing specialty. In the absence of an international curriculum for the study of palliative medicine, this textbook continues to provide the essential guidance for those either embarking upon a career in palliative medicine or already established in the field.

With additional chapters covering all the different aspects of supportive care, the second edition expands upon its unique evidence-based, multi-professional approach and global perspective ensured by the international team of editors and contributing authors. It features an entirely new section on the assessment and management of effects of medical treatments as well as a new section on rehabilitation and survivorship. This edition also contains new material on chemotherapy- and radiation therapy-induced emesis, geriatric palliative care, and hormonal therapy and targeted agents.

With an emphasis on providing palliative service anywhere in the world, including the need to provide such care in developing nations, the book is an ideal complement to the narrative approach of other texts on the topic. It is essential reading for all palliative care physicians in training and in practice, as well as palliative and support care nurses and other health professionals on the palliative care team.


"…the thoroughness of the text has to be admired. It is an excellent starting point for students of palliative care, which makes an important contribution to any library."

British Journal of Hospital Medicine

"This is an excellent palliative medicine resource. The special emphasis on global issues makes it unique in the growing market of palliative medicine books. The additional chapters included in the second edition on the different aspects of supportive care are exceptional."

—Darrell A. Owens, Doody’s, 2015

Table of Contents


Development of Palliative Medicine in the United Kingdom and Ireland

Bill Noble and Michelle Winslow

Development of Palliative Care in Europe

Carl Johan Fürst and Lukas Radbruch

Development of Palliative Care in Canada

John F. Scott, Jose Pereira, and Peter Lawlor

Development of Palliative Medicine in the United States

Charles F. von Gunten

Development of Palliative Medicine in Latin America

Roberto Wenk

Development of Palliative Medicine in Africa

Liz Gwyther, Sue Boucher, and Richard Harding

Development of Palliative Care in Australia and New Zealand

Jane Phillips, Jane M. ingham, and Rod MacLeod

Development of Palliative Medicine in Asia

Satoru Tsuneto

Palliative Care as A Public Health Issue

E. Iris Groeneveld and Irene J. Higginson

Palliative Care as A Primary Care Issue

Scott A. Murray

Future of Palliative Medicine

Charles F. von Gunten, and Irene J. Higginson

Palliative Care and Supportive Care

Eduardo Bruera and David Hui


Bioethical Principles in Palliative Care

Paulina Taboada

Ethics in the Practice of Palliative Care

James A. Tulsky

Dignity in Palliative Care

Susan E. McClement, Harvey Max Chochinov, and Maia Kredentser


Transcultural Palliative Care

Carl Johan Fürst and Solvig Ekblad

Palliative Care: Global Situation and Initiatives

Liliana De Lima


Undergraduate Education in Palliative Medicine

Doreen oneschuk

Graduate Education for Nonspecialists

Ilora G. Finlay and Simon I.R. Noble

Changing the Norms of Palliative Care Practice by Changing the Norms of Education and Quality Improvement: A Case Example

Linda Emanuel


Challenges of Research in Palliative and Supportive Medicine

Irene J. Higginson

The Population: Who Are the Subjects in Palliative Medicine Research?

Claudia Bausewein and Fliss E.M. Murtagh

Study Designs in Palliative Medicine

Massimo Costantini

Outcome Measurement in Palliative Care

Joan M. Teno

Ethics in Palliative Care Research

Jonathan Koffman, Katie Stone, and Fliss E.M. Murtagh

Practical Tips for Successful Research in Palliative Care

Eduardo Bruera and Sriram Yennurajalingam

Audit and Quality Improvement in Palliative Care Research

Hsien-Yeang Seow, Deanna Bryant, Sarah Myers, and Joanne Lynn


Adoption of Palliative Care: The Engineering of Organizational Change

Winford E. (Dutch) Holland

Principles of Measuring the Financial Outcomes of Specialist Palliative Care Programs

J. Brian Cassel and Thomas J. Smith

Organization and Support of the interdisciplinary Team

Karen Macmillan and Louise Kashuba, Bette Emery

Population-Based Needs assessment for Patient and Family Care

Irene J. Higginson and Charles F. von Gunten

Palliative Care Consult Team

Rachel M. Adams, Alexie Cintron, and Diane E. Meier

Models of Palliative Care Delivery

Badi El Osta and Eduardo Bruera

Palliative Home Care

Roberto Wenk

Palliative Day-Care Centers and Day Hospitals

Bruno Gagnon

Inpatient Hospices

Jeremy Keen

Palliative Care Unit

Karen Macmillan, Kelley Fournier, and Beth Tupala


Multidimensional Patient assessment

Marvin Omar Delgado-Guay, Eduardo Bruera

Tools for Pain and Symptom assessment

Victor T. Chang

Quality of Life assessment in Palliative Care

S. Robin Cohen and Richard Sawatzky


Pathophysiology of Chronic Pain

Sebastiano Mercadante

Causes and Mechanisms of Pain in Palliative Care Patients

Marieberta Vidal and Suresh K. Reddy

Opioid Analgesics

Geana Paula Kurita, Stein Kaasa, and Per Sjøgren

Assessment and Management of Opioid Side Effects

Shalini Dalal

Adjuvant Analgesic Drugs

Russell K. Portenoy, Evgenia Krotova, and David Lussier

Alternative Routes for Systemic Opioid Delivery

Carla Ida Ripamonti and Monica Bosco

Spinal Analgesia and Neurolysis

Seiji Hattori

Anesthesiological Procedures in Palliative Care

Sarah Gebauer

Pain Management in Pediatrics

Regina Okhuysen-Cawley

Pain in the Older Adult

Linh My Thi Nguyen and Jen-Yu Wei

Neuropathic Pain

Paolo Marchettini, Fabio formaglio, and Marco Lacerenza

Bone Cancer Pain and Skeletal Complications

Yoko Tarumi

Breakthrough (Episodic) Pain in Cancer Patients

Shirley H. Bush

Symptom Burden, Pain, and the Problems with "Somatization" Diagnosis

Carrie J. Aigner and Diane M. Novy

Pain in Patients with Alcohol and Drug Dependence

Julie R. Price, Steven D. Passik, and Kenneth L. Kirsh


Pathophysiology of Cachexia-Anorexia Syndrome

Egidio Del Fabbro

Overview of the Management of the Anorexia/Weight Loss Syndrome

Cara Bondly and Aminah Jatoi


Sebastiano Mercadante

Constipation and Diarrhea

Jay R. Thomas

Malignant Ascites

Jeremy Keen


Nathan I. Cherny and Batsheva Werman

Malignant Bowel Obstruction

Carla Ida Ripamonti, Alexandra M. Easson, and Hans Gerdes

Endoscopic Treatment of Gastrointestinal Symptoms

Pasquale Spinelli


Pathophysiology of Fatigue

Claudia Gamondi and Hans Neuenschwander

Physical Activity in Palliative and Supportive Care

Sonya S. Lowe, Kerry S. Courneya

Assessment and Management of Fatigue

Sriram Yennurajalingam and Eduardo Bruera



Jay R. Thomas

Other Respiratory Symptoms (Cough, Hiccup, and Secretions)

Sarah Mollart, Tabitha Thomas, Rosemary Wade, and Sara Booth



Tatsuo Akechi and Yosuke Uchitomi


Yesne Alici and William Breitbart

Sleep Disturbances in Advanced Cancer Patients

Sandra L. Pedraza, Dave Balachandran, and Sriram Yennurajalingam

Counseling in Palliative Care

Kimberley Miller and David W. Kissane

Hope in End-of-Life Care

Cheryl L. Nekolaichuk


Dehydration and Rehydration

Robin L. Fainsinger

Fever, Sweats, and Hot Flashes

Ahsan Azhar and Shalini Dalal


Katie Taylor and andrew Thorns

Infections in Palliative Care

Rudolph M. Navari, Christopher Green, Michelle L. Haney, and Nathan L. Roach

Pressure Ulcers/Wounds

Kathryn G. Froiland

Mouth Care

Flavio Fusco


Fabio Fulfaro and Carla Ida Ripamonti

Assessment and Management of Lymphedema

Ying Guo and Benedict Konzen



Kimberson C. Tanco and Paul W. Walker


Jen-Yu Wei and Sriram Yennurajalingam

Spinal Cord Compression

Nora A. Janjan, Stephen Lutz, and Edward Chow

Clinical Features and Management of Superior Vena Cava Syndrome

Álvaro Sanz and Carlos Centeno

Acute Pain and Management

Mellar P. Davis and Pam Gamier


Yesne Alici, Reena Jaiswal, Hayley Pessin, and William Breitbart


Cancer: Radiotherapy

Luluel Khan, Edward Chow, and Elizabeth A. Barnes

Chemotherapy, Hormonal Therapy, and Targeted Agents

David Hui

Physical Medicine and Rehabilitation

Benedict Konzen and Ki Y. Shin

Integrative and Palliative Medicine

Gabriel Lopez, Richard Lee, and Lorenzo Cohen

Human Immunodeficiency Virus and Palliative Care

Richard Harding, Robert E. Hirschtick, and Jamie H. Von Roenn

Neurological Diseases

Tobias Walbert

End-Stage Congestive Heart Failure

Kristian M. Bailey and Mark T. Kearney

Palliative Care for Children

Finella Craig and Julie Bayliss

Geriatric Palliative Care

Kimberson C. Tanco and Maxine de la Cruz

Advanced Chronic Obstructive Pulmonary Disease

Graeme M. Rocker, Joanne Young, and J. Randall Curtis

Other Infectious Diseases: Malaria, Rabies, Tuberculosis

Sue Marsden

Practical Aspects of Palliative Care Delivery in the Developing World

Liliana De Lima and Roberto Wenk

Prognostic indicators of Survival

Caterina Modonesi, Augusto T. Caraceni, and Marco Maltoni

Palliative Sedation

Nathan I. Cherny


Physical and Occupational therapies in Palliative Care

Hitoshi Okamura, Yoshiyuki Masuda, and Hisako Tajiri

Staff Stress and Burnout in Palliative Care

Mary L.S. Vachon and Lise Fillion

Communication in Palliative Care

Josephine M. Clayton and Martin H.N. Tattersall

Spiritual Care

Marvin Omar Delgado-Guay

Family Caregivers

Rony Dev and Mary Dev


Victoria H. Raveis

Children of Palliative Care Patients

Estela Beale


Chemotherapy- and Radiotherapy-induced Emesis

Joseph Arthur

Neutropenic Fever

Hiroshi Ishiguro and Harumi Gomi

Anemia-Related Fatigue

Toshiyuki Kitano and Akifumi Takaori-Kondo

Platelets and Bleeding: Thrombosis Risks

Yukiko Mori

Integrative Medicine in Palliative Care

Robert Alan Bonakdar, Erminia Guarneri, and David C. Leopold

Alternative Medicine: The Approach To the Patient Wanting to Go To Tijuana

Richard Lee, Gabriel Lopez, Daniel Epner, and Michael Fisch

Side Effects of Radiation therapy

Alysa Fairchild and Elizabeth A. Barnes

Cardiac and Pulmonary Toxicities of Treatments

Marieberta Vidal

Oral Complications of Cancer Therapies

Siri Beier Jensen and Deborah P. Saunders

Dermatologic Side Effects

Jen-Yu Wei

Peripheral Neuropathy and Neurotoxicity

Ivo W. Tremont-Lukats and Pedro Garciarena

Sex and Sexuality

Mary K. Hughes

Managing Communication Challenges with Patients and Families

Anthony L. Back

Supportive and Palliative Care for Patients with HIV Infection

Elizabeth J. Chuang and Peter A. Selwyn

Implantable Cardiac Devices

Laura J. Morrison

Supportive Care for Patients with Advanced Chronic Kidney Disease

Sara N. Davison

Palliative Care in the Emergency Department

Travis DeVader and Tammie Quest

Symptom Control in Stem-Cell Transplantation: A Multidisciplinary Palliative Care Team Approach

Eric Roeland, William Mitchell, Carolyn Mulroney, Kathryn Thornberry, Rabia Atayee, and Joseph Ma, Heather Herman


End of therapy: Building the Psychosocial and Spiritual Bridges to Survivorship

Marvin Omar Delgado-Guay and Silvia Tanzi

Rehabilitation in the Acute and Chronic Care Setting

Benedict Konzen and Ying Guo, Ki Y. Shin

Long-Term Cognitive Function

Asao Ogawa

Gonadal Functions and Reproductive Health

Koji Kawai and Hiroyuki Nishiyama

Genetic Counseling in the Palliative Care Setting

Lisa Madlensky, Eric Roeland, and Kim Bower

Pulmonary Rehabilitation

Ryo Kozu

About the Editors

Edited By

Eduardo Bruera, MD, Professor and Chair, Department of Palliative Care and Rehabilitation Medicine, U.T. MD Anderson Cancer Center, Houston, Texas, USA

Irene J. Higginson, BMed Sci, BMBS, FFPHM, PhD, FRCP, Professor and Head of Department, Department of Palliative Care, Policy and Rehabilitation, King's College London, UK

Charles F. von Gunten, MD, PhD, Director, Center for Palliative Studies, San Diego Hospice and Palliative Care, San Diego, California, USA

Tatsuya Morita, MD, Department of Palliative and Supportive Care, Seirei Hospice, and Palliative Care Team, Seirei Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Terminal Care
MEDICAL / Nursing / General
MEDICAL / Oncology