1st Edition

The Benefit/Risk Ratio A Handbook for the Rational Use of Potentially Hazardous Drugs

By Hans C. Korting, M. Schafer-Korting Copyright 1999
    400 Pages
    by CRC Press

    398 Pages
    by CRC Press

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    The use of drugs as remedies for various types of diseases has a long tradition; however, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possible toxicity. The aim of this handbook is to compile data from various authors, providing clinicians with data that will optimize their decision making in selecting effective, low-risk drug treatments. It also provides research workers, including physicians, pharmacists, and basic scientists, with a sound basis for increasing knowledge of the risk/benefit ratios of various drugs.
    Includes detailed assessments of the following types of drugs:

  • Antihypertensive agents
  • Diuretics
  • Anti-diabetic drugs
  • Anticonvulsant drugs
  • Drugs for Parkinson's disease
  • Antihistamines and antiserotonins
  • Cytokines and immunomodulators
  • Non-opioid analgesics and anti-inflammatory agents
  • Antibacterial agents
  • Antiviral agents
  • Drugs used in reproductive endocrinology
  • Systemic drugs for skin diseases
  • Topical liposome drugs
  • Topical glucocorticoids
  • The Role and Analysis of Benefit and Risk in the Development of New Drugs. Prediction of the Benefit/Risk Ratio from In Vitro Data. Evaluation of Therapeutic Benefits and Toxicological Risks Using Structure-Activity Relational Expert Systems. Improving the Therapeutic Index Through Unusual Routes of Application: Intra-Arterial Treatment of Liver Metastases. Establishing the Benefit/Risk Ration with Combination Drugs. Improving the Therapeutic Index of Antineoplastic Agents through Additional Drugs. Antihypertensive Agents. Diueretics. Anti-Diabetic Drugs. Anticonvulsant Drugs and Drugs for Parkinson's Disease. Antihistamines and Antiserotonins. Cytokines and Immunomodulators. Non-Opioid Analgesics and Anti-Inflammatory Agents. Toxicity Profile of Liposomal Anthacyclines. Antibacterial Agents. Antiviral Agents. Drugs Used in Reproductive Endocrinology. Nicotine Preparations in Smoking. Systemic Drugs for Skin Diseases. Topical Liposome Drugs. Topical Glucocorticoids. Index.


    Korting, Hans C. | Schafer-Korting, M.