Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs.
In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases.
This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.
Table of Contents
Blood-Brain Barrier Disruption in Multiple Sclerosis
Portals of Viral Entry into the Central Nervous System
Blood-Brain Barrier Dysfunction in HIV Infection
The Brain Microvasculature in Cerebral Malaria
The Blood-Brain Barrier in Bacterial Infections of the Central Nervous System
The Blood-Brain Barrier in Fungal Infections of the Central Nervous System
Blood-Brain Barrier Changes in Traumatic Brain Injury
Alterations of the Blood-Brain Barrier in Post-Traumatic Epilepsy
Functional and Molecular Mechanisms of Hypertensive Brain Damage
Blood-Brain Barrier Protection in Stroke: Taming tPA
Radiation-induced Blood-Brain Barrier Disruption
Alterations of the Blood-Brain Barrier in Thiamine Deficiency
The Blood-Brain Barrier in Brain Tumors
Cerebral Amyloid Angiopathy
The Blood-Brain Barrier in Neurodegenerative Diseases
Alterations of Blood-Brain Barrier Function by Drugs of Abuse