1st Edition

The Blood-Brain Barrier in Health and Disease, Volume Two
Pathophysiology and Pathology




ISBN 9781498727082
Published October 21, 2015 by CRC Press
394 Pages - 43 Color & 14 B/W Illustrations

USD $185.00

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Book Description

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs.

In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases.

This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Table of Contents

Blood-Brain Barrier Disruption in Multiple Sclerosis

Portals of Viral Entry into the Central Nervous System

Blood-Brain Barrier Dysfunction in HIV Infection

The Brain Microvasculature in Cerebral Malaria

The Blood-Brain Barrier in Bacterial Infections of the Central Nervous System

The Blood-Brain Barrier in Fungal Infections of the Central Nervous System

Blood-Brain Barrier Changes in Traumatic Brain Injury

Alterations of the Blood-Brain Barrier in Post-Traumatic Epilepsy

Functional and Molecular Mechanisms of Hypertensive Brain Damage

Blood-Brain Barrier Protection in Stroke: Taming tPA

Radiation-induced Blood-Brain Barrier Disruption

Alterations of the Blood-Brain Barrier in Thiamine Deficiency

The Blood-Brain Barrier in Brain Tumors

Cerebral Amyloid Angiopathy

The Blood-Brain Barrier in Neurodegenerative Diseases

Alterations of Blood-Brain Barrier Function by Drugs of Abuse

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