The Blood-Cerebrospinal Fluid Barrier: 1st Edition (Hardback) book cover

The Blood-Cerebrospinal Fluid Barrier

1st Edition

Edited by Wei Zheng, Adam Chodobski

CRC Press

656 pages | 2 Color Illus. | 104 B/W Illus.

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Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue.

The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier.

This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.

Table of Contents


Development of the Blood-Cerebrospinal Fluid Barrier, C. Joakim Ek, Katarzyna M. Dziegielewska, and Norman R. Saunders

Normal and Pathologically Altered Structures of the Choroid Plexus, Lise Prescott, and Milton W. Brightman

Junctional Proteins of the Blood-CSF Barrier, Susanne Angelow, and Hans-Joachim Galla


Fluid Compartments of the Central Nervous System, Malcolm B. Segal

Peptide-Mediated Regulation of CSF Formation and Blood Flow to the Choroid Plexus, Joanna Szmydynger-Chodobska and Adam Chodobski

Ion Transporters and Channels Involved in CSF Formation. Peter D. Brown, Tracey Speake, Sarah L. Davies, and Ian D. Millar

Molecular Basis of Xenobiotic Transport and Metabolism in Choroid Plexus, David S. Miller, Simon Lowes, and John B. Pritchard

Homeostasis of Nucleosides and Nucleobases in the Brain: The Role of Flux Between the CSF and the Brain ISF, Transport Across the Choroid Plexus and the Blood-Brain Barrier, and Cellular Uptake, Zoran B. Redzic

Regulation of Neuroactive Metals by the Choroid Plexus, G. Jane Li and Wei Zheng

The Role of the Choroid Plexus in Transport and Production of Polypeptides, Adam Chodobski, Gerald D. Silverberg, and Joanna Szmydynger-Chodobska

Expression of Transthyretin in the Choroid Plexus: Relation to the Brain Homeostasis of Thyroid Hormones, Samantha J. Richardson


Choroid Plexus and CSF in Alzheimer's Disease: Altered Expression and Transport of Proteins and Peptides, Conrad E. Johanson, Gerald D. Silverberg, John E. Donahue, John A. Duncan, and Edward G. Stopa

The Blood-CSF Barrier and Cerebral Ischemia, Richard F. Keep, Steven R. Ennis, and Jianming Xiang

Ageing of the Choroid Plexus and CSF System: Implications for Neurodegeneration, Jane E. Preston, Michael R. Wilson, and Ruo Li Chen

The Role of the Choroid Plexus in HIV-1 Infection, Carol K. Petito

Choroid Plexus and Drug Therapy for Neuro-AIDS, Julie E. Gibbs and Sarah A. Thomas

Blood-CSF Barrier in Iron Regulation and Manganese-Induced Parkinsonism, Wei Zheng

The Involvement of the Choroid Plexus and the Cerebrospinal Fluid in Immune Molecule Signaling in the CNS, Miles Herkenham

Experimental Models of Hydrocephalus: Relation to Human Pathology, Charles E. Weaver and John A. Duncan, III

Clinical Aspects of Disorders of the Choroid Plexus and the CSF Circulation, John D. Pickard, Marek Czosnyka, N. Higgins, B. Owler, S. Momjian, and Alonso Pena

Grafting of the Choroid Plexus: Clinical Implications, Naoya Matsumoto, Yutaka Itokazu, Masaaki Kitada, Shushovan Chakrabortty, Kazushi Kimura, and Chizuka Ide


In situ Techniques Used in the Blood-CSF Barrier Research, Wei Zheng and Malcolm B. Segal

In vitro Investigation of the Blood-Cerebrospinal Fluid Barrier Properties. Primary Cultures and Immortalized Cell Lines of the Choroidal Epithelium, Nathalie Strazielle and Jean-François Ghersi-Egea

In vivo Techniques Used in the Blood-CSF Barrier Research: Measurement of CSF Formation, Adam Chodobski and Malcolm B. Segal

About the Authors/Editors

Wei Zheng, Adam Chodobski

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Anatomy
MEDICAL / Toxicology
SCIENCE / Life Sciences / General
SCIENCE / Life Sciences / Neuroscience