The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research, 1st Edition (e-Book) book cover

The COST Manual of Laboratory Animal Care and Use

Refinement, Reduction, and Research, 1st Edition

Edited by Bryan Howard, Timo Nevalainen, Gemma Perretta

CRC Press

439 pages

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Hardback: 9781439824924
pub: 2010-10-12
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pub: 2016-04-19
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Description

Judge Your Practices Against This Benchmark ManualCOST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the groups' findings, The COS

Table of Contents

Introduction. Design and Oversight of Laboratory Animal Facilities. Housing and Care of Laboratory Animals. Animal Needs and Environmental Refinement. Ethical Evaluation of Scientific Procedures: Recommendations for Ethics Committees. Reduction by Careful Design and Statistical Analysis. Animal Models: Selecting and Preparing Animals for a Study. Creation of Genetically Modified Animals. Management of Genetically Modified Rodents. Impact of Handling, Radiotelemetry, and Food Restriction. Basic Procedures: Dosing, Sampling and Immunisation. Imaging Techniques. Anaesthesia and Analgesia. Use of Humane Endpoints to Minimise Suffering. Euthanasia. Education, Training and Competence. Animal Experimentation and Open Communication.

About the Editors

Bryan Robert Howard is the former Director of Animal Welfare at the University of Sheffield.

Timo Nevalainen is a Professor of the National Laboratory Animal Center at the University of Kuopio.

Gemma Perretta is the Head of the Division of Special Zoology and Animal Models for the Institute of Neurobiology and Molecular Medicine of the Italian National Research Council in Rome.

Subject Categories

BISAC Subject Codes/Headings:
MED089000
MEDICAL / Veterinary Medicine / General
MED106000
MEDICAL / Research
SCI089000
SCIENCE / Life Sciences / Neuroscience