The Chemical Biology of Thrombin  book cover
1st Edition

The Chemical Biology of Thrombin

  • Available for pre-order. Item will ship after February 23, 2022
ISBN 9781138055902
February 23, 2022 Forthcoming by CRC Press
300 Pages 44 B/W Illustrations

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Book Description

This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis.

Key Features

  • Reviews the history of Thrombin (Fibrin Ferment)
  • Documents the relation of protein engineering and chemical modification in the study of thrombin
  • Summarizes the interaction of thrombin with fibrinogen and fibrin
  • Outlines the role of exosites in thrombin function
  • Describes the development of an oral inhibitor for thrombin


Table of Contents

Chapter 1
The History of Thrombin

Chapter 2
The Formation of Thrombin

Chapter 3
Structural Biology of Thrombin

Chapter 4
The use of Protein Engineering (Mutagenesis) to Study Functional Regions in Thrombin
Expression and Characterization of Recombinant Thrombins

Chapter 5
Chemical Modification of Thrombin

Chapter 6
The Interaction of Thrombin with Fibrinogen and Fibrin

Chapter 7
Thrombin and Platelets

Chapter 8
Inhibitors of Thrombin

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Roger L. Lundblad is an independent consultant based in Chapel Hill, North Carolina. He is also an adjunct professor of pathology at the University of North Carolina, Chapel Hill.