The book deals with the chromosomal imbalance (aneuploidy) theory of cancer. The book explains how gene mutations are not powerful enough to cause cancer, describes how cancer is initiated and why progression takes years to decades, and accounts for the global or macroscopic characteristics that readily identify cancer. In addition, it clarifies why cancer cells often become drug resistant even to drugs they were never exposed, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of cancer therapy and prevention. In short, it posits that the autocatalyzed progression of aneuploidy is carcinogenesis.
Table of Contents
Boveri’s Theory of Cancer was Ahead of its Time
Aneuploidy theory "Got Lost"
Genesis of "The Enemy Within"?
Tumor suppressor genes
Gene Mutation Theory of Cancer
"Carcinogens are mutagens
Are "cellular oncogenes" like retroviral oncogenes?
Updated gene mutation theory is popular but unconfirmed
The Chromosomal Imbalance Theory of Cancer
Heuristic explanation of how chromosomal imbalance (and not gene mutation) generates cancer phenotypes
Aneuploidy causes chromosomal instability—the hallmark of cancer
Cancer is a progressive somatic aneuploidy Syndrome
Quantitative analysis of how aneuploidy generates new cellular phenotypes
Theory of Chromosomal Imbalance Solves Mysteries and Paradoxes
Carcinogenesis is dependent on aneuploidy and not mutation
Aneuploidy causes the Warburg effect by increasing ATP demand
Balanced mitotic forces and species-specific sequential chromatid separation may govern the rate of transformation
Cancer vaccine is very unlikely
"Cancers are a genuine type of species"
New Perspectives for Cancer Prevention, Diagnosis and Therapy
International regulation of aneuploidy-inducing agents