1st Edition

Revival: The FOS and JUN Families of Transcription Factors (1994)

By Peter E. Angel, Peter Herrlich Copyright 1994
    322 Pages
    by CRC Press

    322 Pages
    by CRC Press

    This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

    Characteristics of AP-1 Subunits
    Jun Family, Angel and Herrlich
    FOS Family, Schuermann
    Regulation of AP-1 Activity and Synthesis
    Protein/Protein Interactions: Factors Modulating AP-1 Activity, Sassone-Corsi
    Steroid Hormone Receptors/AP-1, Cato
    Post-Translational Modification: Jun Modification, Sachsenmaier and Radler-Pohl
    FOS Modification, Shaw
    Nuclear Uptake, Jeanteur
    Promoter Regulation: C-FOS, Nordheim
    C-Jun, Mechta and Yaniv
    Functions in Physiological Processes
    AP-1 Regulated Target Genes, Busslinger
    Neural Cell Function, Sassone-Corsi
    Differentiation, Rüther
    Stress Response, Rahmsdorf
    Functions in Pathology
    FOS and Jun Oncogenes: FOS in Transformation, Müller
    Jun in Transformation, Vogt
    Oncogenes Acting through FOS and Jun: Raf Kinase, Rapp
    Other Oncogenes, Schönthal
    Adenovirus E1A/AP-1 Connection, van Dam and van der Eb
    Tumor Promotion and Carcinogenesis, Yuspa
    Tumor Progression, Hart

    Biography

    Peter E. Angel, Peter Herrlich