The objective of this volume is to provide a preliminary data base for Candida albicans plus serve as a reference for the genetic methods now available for the manipulation of several species in the genus Candida. This comprehensive review focuses primarily on C. albicans and includes reference data on the types and complementation status of mutations isolated in C. albicans, preliminary recombination mapping, chromosome analysis, physical measurements of DNA content and complexity, mitochondrial genome mapping, and analyses of restriction fragment length polymorphisms. It discusses a variety of genetic techniques in relation to current research questions aimed at virulence factors, dimorphism, and the potential use of Candida strains in biotechnology processes.
This up-to-date publication is an indispensable resource for everyone who is involved with microbiology, genetics, and molecular and cellular biology.
Overview of Candida Physiology, Pathogenicity and New Anticandidal Agents. Molecular Genetics of Candida albicans. Classical Methods for the Genetic Analysis of Candida albicans. Physical Characterization of the Candida albicans Genome. Dimorphism and High Frequency Switching in Candida albicans. Genetic Methods for and Gene Structure in Other Candida Species. The Use of Genetic Analysis in the Study of the Biology of Candida albicans. Molecular Genetics of Candida albicans and Molecular Evolution. Index.