Understanding the Diversity and Complexity of Glycobiology
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This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker.
The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture.
The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
Table of Contents
1. Trends and Advancements in Glycobiology: Towards Development of Glycan-Based Therapeutics
Yaser Rafiq Mir and Raja Amir H. Kuchay
2. Defects in the Human Glycome: Congenital and Non-Congenital Disorders
3. Glycome in Immunological Processes: Current Scenario and Future Prospects
Zeba Mueed, Manali Singh, Abhay Mishra, and Nitesh Kumar Poddar
4. Role of Glycans in Neurodegeneration
Abhai Kumar and Smita Singh
5. Glycome in Metastasis: Glycan Remodeling and Tumor Progression
Ayyagari Archana, Durgashree Dutta, Safikur Rahman, and Rinki Minakshi
6. Glycans in the Host-Pathogen Interaction
Muzafar Jan and Sunil K. Arora
7. Glycome in Microbial Infections and Immune Evasion
8. Acylation as a Vital Post-Glycosylation Modification of Proteins: Insights and Therapeutics Prospects
Usma Manzoor, Snowber Shabir Wani, Fasil Ali, Parvaiz A. Dar, and Tanveer Ali Dar
9. Glycome Profiling in Plants: Towards Understanding the Scenario of Carbohydrates
Reetika Mahajan, Muslima Nazir, Jahangir A. Dar, Shazia Mukhtar, Muntazir Mushtaq, Susheel Sharma, Jasdeep Chatrath Padaria, Shafiq A. Wani, and Sajad Majeed Zargar
10. Sugars: Coping the Stress in Plants
Adeel Malik, PhD, is a Research Professor at the Institute of Intelligence Informatics Technology, Sangmyung University, Seoul, South Korea. He obtained his PhD from the Department of Biosciences, Jamia Millia Islamia (JMI), New Delhi, India. During his PhD, he developed computational methods for the prediction of carbohydrate binding sites in proteins using sequence and evolutionary information. This was the first sequence-based method to predict the carbohydrate binding sites in proteins. Later he joined School of Computational Sciences, Korea Institute for Advanced Study (KIAS), Seoul, South Korea, to pursue his postdoctoral fellowship. As a part of his research, he investigated plant lectin-carbohydrate interactions via community-based network analysis by using glycan array data. He also worked as an Assistant Professor at Perdana University Center for Bioinformatics (PU-CBi), Malaysia from 2014–2016. Dr. Adeel has broad research interests in the area of bioinformatics that include protein-carbohydrate interactions, machine learning, NGS, etc. He has also to his credit several research publications in peer-reviewed international journals, book chapters, and edited books with international publishers.
Tanveer A. Dar, PhD, is Assistant Professor in the Department of Clinical Biochemistry, University of Kashmir, India. Dr. Dar received his master’s degree in Biochemistry from Hamdard University, New Delhi, India, and a PhD in Protein Biophysics from Jamia Millia Islamia, New Delhi, India. After completing his doctorate, Dr. Dar joined as a postdoctorate at the University of Montana, Missoula, USA, where his main research area involved characterization of protein denatured states. Dr. Dar’s research interests mainly include i) structural and functional characterization of glycosylated therapeutic proteins from medicinal plants and ii) role of chemical chaperones/osmolytes in modulating fibrillation/aggregation of proteins. He has authored more than 40 publications in both national and international journals of repute in the field of protein biophysics and proteomics and is also a recipient of an INSA visiting fellowship from the Indian National Science Academy (INSA), India. In addition to this, Dr. Dar has co-authored a number of edited volume books published by internationally reputed publishers, including Springer and Elsevier.