Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse.
Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.
Important Biological Features
Introduction
Stocks and Strains
Nomenclature
Behavior
Anatomic and Physiologic Features
Normative Values
Hematology
Immunodeficient Mice
Wild Mice
References
Husbandry
Housing
Barriers and Containment
Personal Protective Equipment (PPE)
Special Considerations for Immunodeficient Mice
Environment
Sanitation and Pest Control
Nutrition
Water
Breeding
Identification and Record Keeping
Transportation
References
Management
Regulatory Agencies and Compliance
Institutional Animal Care and Use Committee (IACUC)
Occupational Health and Zoonotic Diseases
References
Clinical Medicine
Basic Veterinary Supplies
Physical Examination of the Mouse
Common Spontaneous and Noninfectious Diseases
Common Infectious Diseases
Treatment and Supportive Care of Sick Mice
Clinical Endpoints
Treating Disease on a Colony Basis
References
Preventive Medicine
Receiving
Testing of Biological Materials
Health Surveillance and Monitoring
Disease Prevention through Sanitation
References
Experimental Methodology
Restraint
Sampling Methods
Compound Administration
Phenotyping
Anesthesia and Analgesia
Euthanasia
Necropsy
References
Resources and Additional Information
Organizations
Publications
Electronic Resources
Appendix A: Glossary of Phenotyping Terminology and Tests
Appendix B: Suggested Cassette Numbering System and Some Trimming Suggestions
Index
Biography
Peggy J. Danneman is a Senior Director of Laboratory Animal Health Services at The Jackson Laboratory in Bar Harbor, Maine. Mark A. Suekow is the Director of the Freimann Life Sciences Center at the University of Notre Dame, Indiana. Cory Brayton is the Director of Phenotyping Core for Johns Hopkins Medicine, Maryland.
"This latest in-color edition includes new discussions on disease prevention and testing, transportation, and phenotyping… Overall, this book is well-written and highly applicable to today’s laboratory animal care and use programs … Like the first edition, it is a ‘must have’ for any reference library."
—Robin Crisler-Roberts, DVM, MS, DACLAM, Indiana University School of Medicine, Indianapolis, USA
