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The Modulation of Dopaminergic Neurotransmission by Other Neurotransmitters



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ISBN 9780849347801
Published December 20, 1995 by CRC Press
240 Pages

 
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Book Description

This book presents information from different scientific disciplines - behavioral, biochemical, electrophysiological, anatomical, and medical - to detail the interaction of the neurotransmitter dopamine (DA) with other neurotransmitters or neuromodulators in the brain. Internationally recognized experts discuss the interaction of DA with monoaminergic transmitters such as norepinephrine, GABA, acetylcholine, and serotonin, as well as neuropeptide neurotransmitters/neuromodulators such as neurotensin, cholecystokinin, and the opioid peptides. This is also the first book to include data from positron emission tomography (PET) studies examining the interaction of neurotransmitters in the brain.

Table of Contents

The Modulation Of Dopaminergic Neurotransmission By Norepinephrine, C.R. Ashby, Jr. and J.-P. Tassin
Introduction
The Effect of NE Agonists and Antagonists on DA Cells in the Ventral Tegmental Area (VTA) and Substantia Nigra Pars Compacta (SNC): Electrophysiological Studies
The Effect of Experimental Manipulations of NE and DA Levels in the Brain
Dopamine-ß-Hydroxylase Inhibitors
Lesioning of NE Neurons
The Effect of NE Agonists and Antagonists on DA Release from Brain Slices and on Extracellular Levels of DA as Determined Using Microdialysis
The Effect of the Acute and Chronic Administration of Adrenergic Compounds on DA Utilization, Synthesis, and Turnover: Postmortem Studies
The Effect of NE Agents on DA-Mediated Behaviors
Amphetamine and Apomorphine-Induced Stereotypy and Locomotor Activity
The Effect of NE on Basal Locomotor Activity
The Effect of the Chronic Administration of NE Compounds on DA-Mediated Behaviors
The Effect of the Chronic Administration of NE Compounds on DA-Mediated Behaviors
The Effect of NE Neuronal Lesions on Cortical DA
Effect of Cortical NE Innervation on Regulation of D1 Receptors in the Prefrontal Cortex
Role of NE/DA Interactions in the "Ventral Tegmental Area" Syndrome
Conclusions
Acknowledgments
References
Dopamine-Opioid Interactions In The Basal Forebrain, L. Churchill and P.W. Kalivas
Abbreviations
Introduction
Anatomical Evidence for a Dopamine-Opioid Interaction
Cellular Organization within the Mesolimbic Circuitry
Synaptic Organization within the Mesolimbic Circuitry
Anatomical Modifications in Enkephalinergic Terminals or Neurons after Dopamine Depletion
Biochemical Evidence for a Dopamine-Opioid Interaction
Dopamine and Opioid Receptors Share Molecular Characteristics in Receptor Function and Second Messengers
Opioids May Regulate Dopamine Receptor Action via cAMP-Dependent Phosphorylation
Dopamine May Regulate Enkephalin Levels via Gene Expression Regulators
Electrophysiological Evidence for Dopamine-Opioid Interactions
Behavioral Evidence for Dopamine-Opioid Interactions
Interaction between Dopamine and Opioids in Locomotion
Interactions between Opioids and Dopamine in Reward
Dopamine-Opioid Interactions in Mesolimbic Circuitry Interdependence
Effect of Mesoaccumbens Dopamine Lesions on Opioid-Induced Behaviors
Dopamine-Opioid Interactions in Neuropsychiatry
Conclusions
References
Serotonergic Modulation Of Midbrain Dopamine Systems, M.D. Kelland and L.A. Chiodo
Introduction
Anatomy
5-HT Containing Pathways
5-HT Receptor Subtypes in DA-Rich Areas
Developmental Compensations by 5-HT Neurons Following Neonatal DA Lesions
Electrophysiological Studies
5-HT Modulation of the Basal Activity of DA Neurons
5-HT Modulation of the Pharmacological and Physiological Responsiveness of DA Neurons
Is Sensory Input to DA Neurons Mediated by 5-HT?
The Influence of 5-HT2A and 5-HT3 Receptors: The Mesocortical DA System and Schizophrenia
DA/5-HT Hypothesis of Schizophrenia
Biochemical Studies
Clinical Studies
MDMA: Dual Role for DA and 5-HT
Biochemical and Behavioral Studies
Electrophysiological Studies
Further Evidence for Interactions between 5-HT and DA
5-HT Modulation of DA Release
5-HT Influence on DA-Mediated Behavior
5-HT, Cocaine, and Other Drugs of Abuse
DA Influence on 5-HT Systems
Conclusions
Acknowledgments
References
Electrophysiological And Biochemical Interactions Between Dopamine And Cholecystokinin In The Brain, A.S. Freeman
Introduction
DA Neurons Containing CCK-8S
CCK Receptors
CCK Receptor Subtypes
Selective CCK Receptor Antagonists
Electrophysiological Effects of CCK Peptides and Antagonists
Effects of CCK Peptides and CCK Antagonists on DA Neuronal Activity
CCK Modulation of Impulse-Regulating D2 Autoreceptors
Effects of CCK Peptides on Midbrain Non-DA Neurons
Electrophysiological Effects of CCK-8S in the Forebrain
Biochemical Interactions Between CCK and DA
Effects of CCK Receptor Stimulation on DA Release in the Nucleus Accumbens
Effects of CCK Receptor Stimulation on DA Release in the Caudate Nucleus
Effects of DA Receptor Stimulation on the Release of CCK-8S
Clinical Relevance of CCK
Role of CCK in Neurological Disease
Role of CCK in Psychosis
Possible Role of CCK-8S in Anxiety and Panic
Significance of DA/CCK-8S Colocalization
References
The Modulation Of Midbrain Dopaminergic Systems By Gaba, J.R. Walters and M.L. Pucak
Historical Perspective
GABA Receptors
Localization of GABA Receptors within the Substantia Nigra
GABAergic Terminals in the Substantia Nigra
Intrinsic Sources
Extrinsic Sources
Effects of GABA on DA Cell Physiology
In Vitro
In Vivo
Conclusions
A Strategy For Measuring Neurotransmitter Interactions In Vivo With Positron Emission Tomography (Pet): Neuropsychiatric Implications, G.S. Smith, S.L. Dewey, and J.D. Brodie
Introduction
Definition of the Conceptual Framework
Psychiatric Considerations
Basic Neuroscience Considerations
Neurotransmitter Activity and Interactions Measured with PET: Experimental Data
Methodological Considerations
Modulation of Dopamine Activity by GABA, Acetylcholine, and Serotonin
Modulation of Acetylcholine Activity by Dopamine, Serotonin, and GABA
Summary
Implications of the Experimental Approach
Summary and Future Directions

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