The Modulation of Dopaminergic Neurotransmission by Other Neurotransmitters: 1st Edition (Hardback) book cover

The Modulation of Dopaminergic Neurotransmission by Other Neurotransmitters

1st Edition

By Charles R. Ashby, Jr.

CRC Press

240 pages

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Hardback: 9780849347801
pub: 1995-12-20
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Description

This book presents information from different scientific disciplines - behavioral, biochemical, electrophysiological, anatomical, and medical - to detail the interaction of the neurotransmitter dopamine (DA) with other neurotransmitters or neuromodulators in the brain. Internationally recognized experts discuss the interaction of DA with monoaminergic transmitters such as norepinephrine, GABA, acetylcholine, and serotonin, as well as neuropeptide neurotransmitters/neuromodulators such as neurotensin, cholecystokinin, and the opioid peptides. This is also the first book to include data from positron emission tomography (PET) studies examining the interaction of neurotransmitters in the brain.

Table of Contents

The Modulation Of Dopaminergic Neurotransmission By Norepinephrine, C.R. Ashby, Jr. and J.-P. Tassin

Introduction

The Effect of NE Agonists and Antagonists on DA Cells in the Ventral Tegmental Area (VTA) and Substantia Nigra Pars Compacta (SNC): Electrophysiological Studies

The Effect of Experimental Manipulations of NE and DA Levels in the Brain

Dopamine-ß-Hydroxylase Inhibitors

Lesioning of NE Neurons

The Effect of NE Agonists and Antagonists on DA Release from Brain Slices and on Extracellular Levels of DA as Determined Using Microdialysis

The Effect of the Acute and Chronic Administration of Adrenergic Compounds on DA Utilization, Synthesis, and Turnover: Postmortem Studies

The Effect of NE Agents on DA-Mediated Behaviors

Amphetamine and Apomorphine-Induced Stereotypy and Locomotor Activity

The Effect of NE on Basal Locomotor Activity

The Effect of the Chronic Administration of NE Compounds on DA-Mediated Behaviors

The Effect of the Chronic Administration of NE Compounds on DA-Mediated Behaviors

The Effect of NE Neuronal Lesions on Cortical DA

Effect of Cortical NE Innervation on Regulation of D1 Receptors in the Prefrontal Cortex

Role of NE/DA Interactions in the "Ventral Tegmental Area" Syndrome

Conclusions

Acknowledgments

References

Dopamine-Opioid Interactions In The Basal Forebrain, L. Churchill and P.W. Kalivas

Abbreviations

Introduction

Anatomical Evidence for a Dopamine-Opioid Interaction

Cellular Organization within the Mesolimbic Circuitry

Synaptic Organization within the Mesolimbic Circuitry

Anatomical Modifications in Enkephalinergic Terminals or Neurons after Dopamine Depletion

Biochemical Evidence for a Dopamine-Opioid Interaction

Dopamine and Opioid Receptors Share Molecular Characteristics in Receptor Function and Second Messengers

Opioids May Regulate Dopamine Receptor Action via cAMP-Dependent Phosphorylation

Dopamine May Regulate Enkephalin Levels via Gene Expression Regulators

Electrophysiological Evidence for Dopamine-Opioid Interactions

Behavioral Evidence for Dopamine-Opioid Interactions

Interaction between Dopamine and Opioids in Locomotion

Interactions between Opioids and Dopamine in Reward

Dopamine-Opioid Interactions in Mesolimbic Circuitry Interdependence

Effect of Mesoaccumbens Dopamine Lesions on Opioid-Induced Behaviors

Dopamine-Opioid Interactions in Neuropsychiatry

Conclusions

References

Serotonergic Modulation Of Midbrain Dopamine Systems, M.D. Kelland and L.A. Chiodo

Introduction

Anatomy

5-HT Containing Pathways

5-HT Receptor Subtypes in DA-Rich Areas

Developmental Compensations by 5-HT Neurons Following Neonatal DA Lesions

Electrophysiological Studies

5-HT Modulation of the Basal Activity of DA Neurons

5-HT Modulation of the Pharmacological and Physiological Responsiveness of DA Neurons

Is Sensory Input to DA Neurons Mediated by 5-HT?

The Influence of 5-HT2A and 5-HT3 Receptors: The Mesocortical DA System and Schizophrenia

DA/5-HT Hypothesis of Schizophrenia

Biochemical Studies

Clinical Studies

MDMA: Dual Role for DA and 5-HT

Biochemical and Behavioral Studies

Electrophysiological Studies

Further Evidence for Interactions between 5-HT and DA

5-HT Modulation of DA Release

5-HT Influence on DA-Mediated Behavior

5-HT, Cocaine, and Other Drugs of Abuse

DA Influence on 5-HT Systems

Conclusions

Acknowledgments

References

Electrophysiological And Biochemical Interactions Between Dopamine And Cholecystokinin In The Brain, A.S. Freeman

Introduction

DA Neurons Containing CCK-8S

CCK Receptors

CCK Receptor Subtypes

Selective CCK Receptor Antagonists

Electrophysiological Effects of CCK Peptides and Antagonists

Effects of CCK Peptides and CCK Antagonists on DA Neuronal Activity

CCK Modulation of Impulse-Regulating D2 Autoreceptors

Effects of CCK Peptides on Midbrain Non-DA Neurons

Electrophysiological Effects of CCK-8S in the Forebrain

Biochemical Interactions Between CCK and DA

Effects of CCK Receptor Stimulation on DA Release in the Nucleus Accumbens

Effects of CCK Receptor Stimulation on DA Release in the Caudate Nucleus

Effects of DA Receptor Stimulation on the Release of CCK-8S

Clinical Relevance of CCK

Role of CCK in Neurological Disease

Role of CCK in Psychosis

Possible Role of CCK-8S in Anxiety and Panic

Significance of DA/CCK-8S Colocalization

References

The Modulation Of Midbrain Dopaminergic Systems By Gaba, J.R. Walters and M.L. Pucak

Historical Perspective

GABA Receptors

Localization of GABA Receptors within the Substantia Nigra

GABAergic Terminals in the Substantia Nigra

Intrinsic Sources

Extrinsic Sources

Effects of GABA on DA Cell Physiology

In Vitro

In Vivo

Conclusions

A Strategy For Measuring Neurotransmitter Interactions In Vivo With Positron Emission Tomography (Pet): Neuropsychiatric Implications, G.S. Smith, S.L. Dewey, and J.D. Brodie

Introduction

Definition of the Conceptual Framework

Psychiatric Considerations

Basic Neuroscience Considerations

Neurotransmitter Activity and Interactions Measured with PET: Experimental Data

Methodological Considerations

Modulation of Dopamine Activity by GABA, Acetylcholine, and Serotonin

Modulation of Acetylcholine Activity by Dopamine, Serotonin, and GABA

Summary

Implications of the Experimental Approach

Summary and Future Directions

Subject Categories

BISAC Subject Codes/Headings:
MED057000
MEDICAL / Neuroscience
MED071000
MEDICAL / Pharmacology
MED105000
MEDICAL / Psychiatry / General
SCI086000
SCIENCE / Life Sciences / General