Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.
Table of Contents
Molecular Pathology of Autoimmune Diseases: An Overview Section I. Basic Aspects of Autoimmune Processes. B Cell Tolerance and Autoimmunity. Genetic Origin of Human Autoantibodies. Genetic Origin of Murine Autoantibodies. T Cell Development and Tolerance. T Cell Antigen Receptors and Autoimmune Repertoires. Autoimmune T Cell Recognition: Structural Insights. TCR Signaling Pathways and Their Relevance to Autoimmunity. Cytokines and the Th1/Th2 Paradigm in Autoimmunity. T Cell Adhesion Molecules in Autoimmunity. Apoptosis and Autoimmunity. Processing and Presentation of Self-Antigens. The Role of HLA in Autoimmune Diseases. Antigenic Mimicry in Autoimmune Diseases. The Idiotypic Network in Autoimmunity. Chemokine Receptors as Regulators of Dendritic Cell and Lymphocyte Traffic: Relevance to Autoimmunity. Complement and Complement Receptors in Autoimmunity Section II. Systemic Autoimmune Diseases. Human Systemic Lupus Erythematosus. Abnormalities in B Cell Activity and the Immunoglobulin Repertoire in Human Systemic Lupus Erythematosus. The Anti-Phospholipid Syndrome. Genes and Genetics of Murine Lupus. Rheumatoid Arthritis. Experimental Animal Models of Rheumatoid Arthritis. Sjogren's Syndrome: An Autoimmune Exocrinopathy. Experimental Models of Sjogren's Syndrome. Systemic Sclerosis (Scleroderma). Systemic Vasculitis Section III. Organ-Specific Autoimmune Diseases. Hematologic Autoimmune Diseases. Autoimmune Hemolytic Anemia. Experimental Models of Autoimmune Hemolytic Anemia. Autoimmune Thrombocytopenic Purpura. Experimental Model of Thrombocytopenic Purpura. Autoimmune Neutropenia. Endocrine Autoimmune Diseases. Human Autoimmune Diabetes. Animal Models of Type I Diabetes. The Autoimmune Response in A Transgenic Mouse Model of Insulin-Dependent Diabetes. Hashimoto's Disease. Immunological Mechanisms in Grave's Disease. Experimental Models in Autoimmune Thyroiditis. Autoimmune Polyglandular Syndrome's and Addison's Disease. CNS Autoimmune Diseases. Molecular Pathology of Multiple Sclerosis. Experimental Autoimmune Encephalomyelitis. Autoimmune Diseases of Muscle. Myasthenia Gravis. Experimental Autoimmune Myasthenia Gravis. Autoimmune Disease of the Skin. Vitiligo. Pemphigus. Gastrointestinal Autoimmune Diseases. Immunopathological Conditions Affecting Oral Tissues. Behcet's Disease. Autoimmune Gastritis and Pernicious Anemia. An Experimental Model of Autoimmune Gastritis. Immunoregulatory Defects in Inflammatory Bowel Disease. Experimental Models of Inflammatory Bowel Disease. Hepatic Autoimmune Diseases. Molecular Considerations and Immunopathology of Primary Biliary Cirrhosis. Autoimmune Hepatitis. Cardiovascular Autoimmune Diseases. Autoimmune Myocarditis. Autoimmunity in Atherosclerosis. Other Organ-Specific Autoimmune Diseases. Autoimmune Disease of the Eye. Autoimmune Renal Disease Involving Renal Basement Membrane Antigens. Autoimmune Disease of the Spermatozoa, Ovary and Testes Section IV. Associated Autoimmunity. HIV Infection and Autoimmunity. Transplantation and Autoimmunity. Self-Reactive Residual Repertoires After Tolerance Induction and Their Use in Anti-Tumor Immune Responses. The Nature and Significance of Age-Associated Autoimmunity Section V. Immunotherapeutic Approaches. Autoimmune Diseases as Stem Cell Disorders: Treatment by Allogenic Bone Marrow Transplant. Immunointervention in Autoimmune Diseases.