This book provides essential worldwide reference information regarding rabies for public health officials, veterinarians, physicians, virologists, epidemiologists, infectious disease specialists, laboratory diagnosticians, and wildlife biologists. The book is divided into six main sections, covering topics such as the rabies virus, including antigenic and biochemical characteristics; pathogenesis, including the immune response to the infection, pathology, and latency; diagnostic techniques; rabies epidemiology in a variety of wild and domestic animals; rabies control, including vaccination of wild and domestic animals, as well as control on the international level; and finally a discussion of rabies in humans, local wound and serum treatment, and human post-exposure vaccination. Natural History of Rabies, First Edition has been the principal worldwide reference since 1975. The new Second Edition has been completely updated, providing current information on this historically deadly disease.
"…a marvelous book…eminently readable, instructive…will stand the test of time."
-The Veterinary Record
HISTORY OF RABIES. THE VIRUS. Overview. Chemical Composition and Structure of Rabies Virus-B. Antigenic Composition of Rabies Virus-C. PATHOGENESIS AND PATHOLOGY. Overview. Pathogenesis to the Central Nervous System. Spread of Virus Within the Central Nervous System. Spread of Virus from the Central Nervous System. The Immune Response to Rabies Infection. The Pathology of Rabies in the Central Nervous System. Latency and Abortive Rabies. DIAGNOSIS. Overview. Rabies Diagnosis by Animal Inoculation, Identification of Negri Bodies, or ELISA. The Fluorescent Antibody Test in Rabies. The Serum Neutralization Indirect Fluorescent Antibody, and Rapid Fluorescent Focus Inhibition Tests. EPIDEMIOLOGY. Overview. Fox Rabies. Arctic Fox Rabies. Rabies in Skunks. Raccoon Rabies. Rabies in Non-Hematophagous Bats. Canine Rabies. Cat Rabies. Bovine Paralytic Rabies and Rabies in the Vampire Bat. Rodent Rabies. RABIES CONTROL. Overview. Canine and Feline Vaccines-Past and Present. Control of Urban Rabies. Vaccines for Domestic Animals-Past and Present. The Biology and Control of Vampire Bats-Flores Crespo and Arellano. Control of Rabies Among Terrestrial Wildlife by Population Reduction. Wildlife Vaccination. International Management of Rabies. RABIES AND ITS PREVENTION IN MAN. Overview. Rabies in Man. Local Wound Treatment and Passive Immunization. Human Vaccination Against Rabies. APPENDIX: GUIDE FOR POST-EXPOSURE TREATMENT.