The Neurobiological Basis of Suicide: 1st Edition (Hardback) book cover

The Neurobiological Basis of Suicide

1st Edition

Edited by Yogesh Dwivedi

CRC Press

482 pages | 4 Color Illus. | 34 B/W Illus.

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pub: 2012-06-25
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With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology.

Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior.

The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Table of Contents

Diagnosis, Traits, States, and Comorbidity in Suicide

Jan Fawcett

Neuroanatomy of Serotonergic Abnormalities in Suicide

Helene Bach and Victoria Arango

Noradrenergic Dysfunction in Depression and Suicide

Michelle J. Chandley and Gregory A. Ordway

Gamma-Aminobutyric Acid Involvement in Depressive Illness: Interactions with Corticotropin-Releasing Hormone

and Serotonin

Hymie Anisman, Zul Merali, and Michael O. Poulter

Role of the Endocannabinoid System in the Neurobiology of Suicide

K. Yaragudri Vinod

Stress–Diathesis Model of Suicidal Behavior

Kees van Heeringen

Do Serum Cholesterol Values and DST Results Comprise Independent Risk Factors for Suicide?

William Coryell

Brain-Derived Neurotrophic Factor in Suicide Pathophysiology

Yogesh Dwivedi

Neuroimaging: High Risk States for Suicide

Jeffrey H. Meyer

Gene–Environment Interaction and Suicidal Behavior

Alec Roy

Genetic Factors and Suicidal Behavior

Clement C. Zai, Vincenzo de Luca, John Strauss, Ryan P. Tong, Isaac Sakinofsky, and James L. Kennedy

Approaches and Findings from Gene Expression Profiling Studies of Suicide

Laura M. Fiori and Gustavo Turecki

Epigenetic Effects of Childhood Adversity in the Brain and Suicide Risk

Benoit Labonté and Gustavo Turecki

Genetics of Suicidal Behavior in Children and Adolescents

Gil Zalsman

Neurobiology of Teenage Suicide

Ghanshyam N. Pandey and Yogesh Dwivedi

Suicidal Behavior in Pediatric Population: Neurobiology and the Missing Links in Assessing Risk among Patients with Bipolar Disorder

Sonali Nannayakkara, Kiran Pullagurla, and Mani Pavuluri

Suicide in Late Life

Olusola A. Ajilore and Anand Kumar

Intermediate Phenotypes in Suicidal Behavior: Focus on Personality

Dan Rujescu and Ina Giegling

Toxoplasma gondii, the Immune System, and Suicidal Behavior

Olaoluwa Okusaga and Teodor T. Postolache

Peripheral Biomarkers for Suicide

Ghanshyam N. Pandey and Yogesh Dwivedi

Medication in Suicide Prevention: Insights from Neurobiology of Suicidal Behavior

J. John Mann and Dianne Currier

About the Editor

Yogesh Dwivedi is with the Department of Psychiatry at the University of Illinois.

About the Series

Frontiers in Neuroscience

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Psychiatry / General
SCIENCE / Life Sciences / Neuroscience