The Neurobiology of Cocaine: Cellular and Molecular Mechanisms, 1st Edition (Hardback) book cover

The Neurobiology of Cocaine

Cellular and Molecular Mechanisms, 1st Edition

By Ronald P. Hammer, Jr.

CRC Press

272 pages

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Hardback: 9780849383113
pub: 1995-07-17
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Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain. Recent developments of cellular, molecular, and brain imaging methods provide new evidence that chemical and molecular substrates underlie cocaine reinforcement, dependence, and withdrawal. This book explores the biological bases of such effects, describing the brain circuits affected by cocaine, neuroendocrine and neurophysiological actions of cocaine, neurochemistry and pharmacology of cocaine, and cocaine effects on signal transduction, gene expression, and protein phosphorylation.

This up-to-date text also describes the recently cloned class of neurotransporters affected by cocaine and characterizes their interaction with the drug. These reports focus on the effects of chronic exposure and subsequent withdrawal, which are differentiated from acute cocaine actions. Thus, they provide information on brain mechanisms likely active during long-term use and abuse in humans. Such commonalities are illustrated by a discussion of cocaine action in the human brain as visualized by positron emission tomography. This volume is a must for anyone interested in the mechanisms underlying cocaine abuse.

Table of Contents

Mechanisms of Cocaine Reinforcement

Neuroanatomical Basis of Cocaine Self-Administration, J.H. Graham and L.J. Porrino

Regional Metabolic Manifestations of Cocaine Exposure: Sensitization, Tolerance, and Withdrawal, R.P. Hammer, Jr., B.B. Young, and W.L. Thomas, Jr.

Sensitization and Tolerance to the Motivational and Subjective Effects of Psychostimulants, M.W. Emmett-Oglesby

Neuroendocrine Effects of Cocaine, C.M. Kuhn and P.J. Little

Cocaine Action in Humans, N.D. Volkow and J.S. Fowler

Cellular Effects of Cocaine

Neural Basis of Behavioral Sensitization to Cocaine, P.W. Kalivas

Neurophysiological Alterations in the Mesocorticolimbic Dopamine System with Repeated Cocaine Administration, F.J. White, X.-T. Hu, D.J. Henry, and X.-F. Zhang

Modulation of Serotonin Function by Acute and Chronic Cocaine: Neurophysiological Analyses, K.A. Cunningham

Cocaine Interactions with the Endogenous Opioid System, E. Unterwald

Neurochemistry of Cocaine Withdrawal, F. Weiss, L.H. Parsons, and A. Markou

Chronic Cocaine Action on the Dopamine Transporter, N.R. Zahniser, G.A. Gerhardt, and W.A. Cass

Molecular Approaches to Studying Cocaine Activation

Cocaine and Dopamine Transporters, M.J. Kuhar, J.W. Boja, A. Patel, N. Pilotte, C. Cerruti, and J. Lever

Effects of Cocaine on Immediate-Early Gene Response in Striatal Neurons, A.M. Graybiel, S. Berretta, R. Moratalla, F.-C. Liu, and B. Elibol

Cocaine Regulation of Signal Transduction Pathways, L.W. Fitzgerald and E.J. Nestler

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Toxicology
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / General
SCIENCE / Life Sciences / Neuroscience