This collection of reports by eminent researchers provides a complete description of the effects of opiates on the central nervous system of developing and adult animals. The work is useful to investigators interested in opiate neurobiology and clinicians seeking to understand opiate abuse.
The Neurobiology of Opiates is organized into sections which describe the wide diversity of opiate actions from cellular and molecular to developmental and behavioral. Normal functions of endogenous opioid peptides and functional effects of exogenous opiate exposure are examined using the latest in vivo and in vitro methods. Particular emphasis is placed on the physiological and pharmacological effects of opiate dependence and withdrawal, in addition to the mechanism of opiate reinforcement and molecular mechanisms of opiate regulation. Opiate actions on the developing brain and in the hypothalamo-pituitary-adrenal axis are also discussed. This comprehensive text provides readers with the latest results and challenges them with new directions for opiate research.
Developmental Effects of Opiates: Effects of Opioids on the Developing Brain (R.P. Hammer, Jr.). Opiates and the Regulation of Nervous System Development: Evidence from In Vitro Studies (K.F. Hauser and A. Stiene-Martin). Reinforcing Properties of Opiates during Early Development (G.A. Barr). Ontogency and Plasticity of Opiate Systems (F.M. Leslie and S.E. Loughlin). Cellular Effects of Opiates: Opiate Receptor Regulation by Opiate Agonists and Antagonists (L.S. Brady). Anti-Opioid Peptides in Morphine Tolerance and Dependence (R.B. Rothman, H. Xu, H.-Y.T. Yang , and J.B. Long). Functional Anatomy of Opiate Withdrawal (G.F. Wooten). Opiates Influence Locus Coeruleus Neurons by Potent Indirect and Direct Actions (G. Aston-Jones, R. Shiekhattar, H. Akaoka, J. Rajkowski, and P. Kubiak). Excitatory Amino Acids Interact with Opioid Peptides to Regulate Neuronal Excitability and Gene Expression in the Rat Hippocampal Formation (J.F. McGinty). Molecular Effects of Opiates: Regulation of Opioid Peptides by Self-Administered Drugs (K.A. Trujillo, D.M. Bronstein, and H. Akil). Stimulus-Transcription Coupling at the m Opiate Receptor (M.M. Garcia and R.E. Harlan). Opiate Regulation of Signal Transduction Pathways (H.W. Harris and E.J. Nestler). Behavioral Effects of Opiates: Neurobiological Substrates of Opioid Abuse (S.I. Dworkin, L.J. Porrino, and J.E. Smith). Reinforcing Effects of Opiates-Modulation by Dopamine (E.M. Unterwalk and C. Kornetsky).