Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation. New information indicates that electric fields play a role in initiating and coordinating complex regenerative responses in development and wound repair and that they may also have a part in cancer progression and metastasis.
Compiling current research in this rapidly expanding field, Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer highlights relevant, cutting-edge topics poised to drive the next generation of medical breakthroughs. Chapters consider methods for detecting endogenous electric field gradients and studying applied electric fields in the lab. The book addresses bioelectricity’s roles in guiding cell behavior during morphogenesis and orchestrating higher order patterning. It also covers the response of stem cells to applied electric fields, which reveals bioelectricity as an exciting new player in tissue engineering and regenerative medicine.
This book provides an in-depth exploration of how electric signals control corneal wound repair and skin re-epithelialization, angiogenesis, and inflammation. It also delves into the bioelectric responses of cells derived from the musculoskeletal system, bioelectrical guidance of neurons, and the beneficial application of voltage gradients to promote regeneration in the spinal cord. It concludes with a discussion of bioelectricity and cancer progression and the potential for novel cancer biomarkers, new methods for early detection, and bioelectricity-based therapies to target both the tumor and metastatic cancer cells.
This multidisciplinary compilation will benefit biologists, biochemists, biomedical scientists, engineers, dermatologists, and clinicians, or anyone else interested in development, regeneration, cancer, and tissue engineering. It can also serve as an ideal textbook for students in biology, medicine, medical physiology, biophysics, and biomedical engineering.
Table of Contents
Measuring Endogenous Electric Fields, R. Nuccitelli
Investigation Systems to Study the Biological Effects of Weak Physiological Electric Fields, F.X. Hart
Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm, M. Levin
Stem Cell Physiological Responses to Noninvasive Electrical Stimulation, I. Titushkin, S. Sun, V. Rao, and M. Cho
Electrical Signals Control Corneal Epithelial Cell Physiology and Wound Repair, C.D. McCaig
Physiological Electric Fields Can Direct Keratinocyte Migration and Promote Healing in Chronic Wounds, C.E. Pullar
Electrical Control of Angiogenesis, E. Wang, Y. Yin, H. Bai, B. Reid, Z. Zhao, and M. Zhao
Inflammatory Cell Electrotaxis, F. Lin and C.E. Pullar
Effects of DC Electric Fields on Migration of Cells of the Musculoskeletal System, N.J. Gunja, C.T. Hung, and J.C. Bulinski
Neuronal Growth Cone Guidance by Physiological DC Electric Fields, A.M. Rajnicek
Can Applied Voltages Be Used to Produce Spinal Cord Regeneration and Recovery in Humans? R.B. Borgens
Bioelectricty of Cancer: Voltage-Gated Ion Channels and Direct-Current Electric Fields, M.B.A. Djamgoz
Christine E. Pullar is a lecturer at the University of Leicester in the UK. She received her Ph.D. in immune cell signal transduction from the University of Sheffield, UK. The Wellcome Trust, the Medical Research Council, and the British Skin Foundation currently fund her lab. Her work has a strong translational flair, including projects that aim to promote healing in chronic wounds and reduce wound scarring, and she hold several patents in this area. She has delivered invited lectures at more than 20 international meetings and is active in mentoring young scientists within the research community.