The Radiation Biology of the Vascular Endothelium: 1st Edition (Hardback) book cover

The Radiation Biology of the Vascular Endothelium

1st Edition

By David B. Rubin

CRC Press

272 pages

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Hardback: 9780849348402
pub: 1997-12-29
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Endothelial cells are early targets of radiation injury. Because these cells are tissues easily damaged by radiation, if we can understand the causes of radiation injury, then normal cells can be well protected and tumors can be destroyed. The Radiation Biology of the Vascular Endothelium brings together expert reviews on the biology and radiobiology of the vasculature, with emphasis on the endothelial cell component of blood vessels.

The book covers both the basic aspects of endothelial cell biology and the practical consequences of this for the oncologist, with special reference to the radiation oncologist. After reading The Radiation Biology of the Vascular Endothelium, no clinical or experimental oncologist should be able to ignore the intimate relationship between tumor and normal tissue cells and endothelial cells that form the barrier to, and are the bearers of, essential nutrient supplies.

Table of Contents

Foreword, J. Denekamp

The Endothelial Cell is a Unique Target of Radiation: An Overview, L.F. Fajardo

The Histopathology of Irradiated Endothelium, D.B. Rubin and M.L. Griem

Functional Measures of Endothelial Integrity and Pharmacologic Modification of Radiation Injury, M.M. Graham and L.M. Peterson

Antioxidant Defenses and the Irradiated Endothelium, D.B. Rubin, E.A. Drab, and E.R. Blazek

Protein Synthesis in Irradiated Endothelial Cells, E.M. Rosen and I.D. Goldberg

Signaling in the Radiation Response of Endothelial Cells, A. Haimovitz-Friedman and Z. Fuks

Effect of Ionizing Radiation on Endothelial Cell Plasma Membrane Processes, L. Kwock, A.W. Blackstock, and M. Friedman

Inflammatory Cytokines, Radiation, and Endothelial Gene Products: A Common Role for Reactive Oxygen Intermediates, J.C. Murray

Extracellular Matrix Regulates Endothelial Cell Morphology, Receptor Expression, and Response to Low Dose Radiation, J.M. Onoda, S.S. Kantak, and C.A. Diglio

Endothelial-Oriented Strategies to Spare Normal Tissues, W.F. Ward, A Molteni, and C.-H. Ts'ao

Tumor Bed Phenomenon: Effect on Tumor Progression and Therapy, L. Milas and M. Milas

Photodynamic Therapy and Endothelial Cells, D.C. West and J.V. Moore


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
MEDICAL / Radiology & Nuclear Medicine