The Textbook of Nanoneuroscience and Nanoneurosurgery: 1st Edition (Hardback) book cover

The Textbook of Nanoneuroscience and Nanoneurosurgery

1st Edition

Edited by Babak Kateb, John D. Heiss

CRC Press

602 pages | 147 B/W Illus.

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pub: 2013-07-25
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Nanoneuroscience, nanoneurosurgery, and nanobioelectronics have the potential to revolutionize medicine and improve the prevention, diagnosis, and treatment of neurological disorders over the next 10-20 years. The Textbook of Nanoneuroscience and Nanoneurosurgery presents a state-of-the-art review of the field, providing current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology.

The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic, as well as the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may significantly impact the field in the near future. Chapters discuss the latest science and technologies—which are applied to diagnosis and treatment of neurological disorders—as well as regulatory issues that impact product development.

This volume describes advances that have already been translated to the clinic or hold significant promise for future application in nanoneurosurgery, as well as their potential impact. A full-color text, the book contains contributions by more than 120 researchers, original and descriptive illustrations, and more than 3,000 references. Offering broad coverage of nanotechnological applications in diverse areas and addressing FDA regulation and healthcare policy, this volume provides a foundation of ideas and methods for scientists and physicians to devise successful, less invasive procedures for future treatment of nervous system disorders.


"…a significant contribution to the field of nanoneuroscience and nanoneurosurgery … the reader will come away with a deeper understanding of the history of nanotechnology and medicine."


"This is a monumental first textbook on nanoneurosurgery. … recommended reading for neurosurgeons, neurologists, neuroradiologists and neuroscientists involved in research on new techniques for application in neurosurgery. Biomedical engineers and various companies developing instruments and devices would benefit from the wealth of information about trends for development of new technologies for neurosurgery."

—K. K. Jain, MD, Basel, Switzerland

Table of Contents

Chapter 1:

From Nanotechnology to Nanoneuroscience/Nanoneurosurgery and Nanobioelectronics: A Historical Review of Milestones

Vicky Yamamoto, Giancarlo Suffredini, Shouleh Nikzad, Michael E. Hoenk, Miriam S. Boer, Charlie Teo, John D. Heiss, and Babak Kateb

Chapter 2:

Nanoneurology and Nanoneurosurgery

Geoffrey S. F. Ling, Robbin Miranda, and Gill Pratt

Chapter 3:

Nanopolymers and Nanoconjugates for Central Nervous System Diagnostics and Therapies

Giancarlo Suffredini and Lucien M. Levy

Chapter 4:

Micelles and Liposomes: Lipid Nanovehicles for Intracerebral Drug Delivery

Massimo S. Fiandaca and Krystof S. Bankiewicz

Chapter 5:

Peptide and Protein-Based Nanoparticles

Ayaz M. Khawaja and John D. Heiss

Chapter 6:

Endohedral Metallofullerenes, Iron Oxide Agents, and Gold Nanoparticles for Brain Imaging

Martina A. McAteer and Robin P. Choudhury

Chapter 7:

Carbon Nanoplatforms and Their Application for Neurological Disorders

Houman Badrzadeh, Peyman Tashkandi, Michelle Knosp, and Babak Kateb

Chapter 8:


Ayaz M. Khawaja and John D. Heiss

Chapter 9:

Ligand-Based Targeting of Therapeutic and Imaging Agents for Cancer

Qimeng Quan, Seulki Lee, and Xiaoyuan Chen

Chapter 10:

Immune-Based Targeting in Cancer

Dwain K. Irvin, Chirag G. Patil, and Keith L. Black

Chapter 11:

Directed Drug Convection Using Magnetic Nanoparticles as Therapeutic Carriers: Meeting the Challenge of Specific Brain Pharmacotherapeutics, Non-Ligand-Based Central Nervous System Targeting, Including Magnetic Focusing

David F. Moore, Vinith Yathindranath, Torsten Hegmann, Donald Miller, Marc Pelletier, and Raphael Schiffmann

Chapter 12:

Intralesional and Intraparenchymal Convection-Enhanced Delivery of Nanoparticles

Tatsuhiro Fujii, Daniel Angeles, Li-Chen Hsu, Rahul Jandial, and Mike Chen

Chapter 13:

Transport of Nanoparticles across Blood–Brain Barrier

Robert T. Wicks, Zev A. Binder, and Alessandro Olivi

Chapter 14:

Nanomedicine Treatment Strategies That Exploit Unique Characteristics of Tumor Vasculature and Microenvironment

Jun Wu, Tats Fujii, and Mike Y. Chen

Chapter 15:

Focused Ultrasound for Noninvasive Neuromodulation

Martin O. Culjat, Richard E. Fan, Meghedi Babakhanian, Amit P. Mulgaonkar, Rahul S. Singh, Warren S. Grundfest, and William P. Melega

Chapter 16:


J. Matthew Dubach and Heather A. Clark

Chapter 17:

Implantable Infusion Pumps Incorporating Nanotechnology

Ellis Meng, Tuan Hoang, and Uttam Sinha

Chapter 18:

Nanostructured Surfaces for Intracerebral Neurotransmitter Recording

David A. Price, Artin Petrossians, Pooja M. Talauliker, Francois Pomerleau, Peter Huettl, Florian Mansfeld, James Weiland, J. Todd Hastings, and Greg A. Gerhardt

Chapter 19:

Therapy for Neuronopathic Lysosomal Storage Diseases

Ayaz M. Khawaja, John D. Heiss, and Roscoe O. Brady

Chapter 20:

Nanotechnology for Cerebral Aneurysm Treatment

Jean Paul Allain, Teodoro Tigno, and Rocco Armonda

Chapter 21:

Improving Treatment of Stroke through Nanotechnology

Francesca Nicholls, Natalia Gorenkova, Ellen Bible, Christy Franco, David Chau, Christos Tolias, Kevin Shakesheff, Jennifer West, and Michel Modo

Chapter 22:

Molecular Medical Devices for Nanoneurosurgery

Rutledge Ellis-Behnke

Chapter 23:

Applications of Nanotechnology in Epilepsy

Paul R. Carney

Chapter 24:

Applications of Nanotechnology to Diseases of the Spine

Bryn S. Moore and Steven A. Toms

Chapter 25:

Nanoparticle-Based Treatment and Imaging of Brain Tumors: Potentials and Limitations

Bong-Seop Lee, Christopher J. Hanson, Rina Amatya, Esther Chung, Mansur Ghani, Allen Yen, Keith L. Black, and John S. Yu

Chapter 26:

Tumor-Targeted Nanodrugs for Treatment of Primary Brain Tumors

Joseph Cheatle and Michele Aizenberg

Chapter 27:

Application of Nanotechnology in the Diagnosis and Treatment of Brain Metastasis

Joel C. Sunshine, Zachary D. Guss, Jay J. Pillai, and Michael Lim

Chapter 28:

Nanotechnology in Extra-Axial and Pituitary Tumors

Aimee Two, J. Peter Gruen, and Gabriel Zada

Chapter 29:

Using Nanoparticles in Diagnosis and Treatment of CNS Infection

Zion Zibly, Cody D. Schlaff, and John D. Heiss

Chapter 30:

Applications of Nanotechnology in Movement Disorders

Patrick Pezeshkian, Karlo J. Lizarraga, Alessandra Gorgulho, and Antonio De Salles

Chapter 31:

Nanomedicine in Demyelinating Disease: Application to Diagnosis and Therapy in Multiple Sclerosis

Emily C. Leibovitch and Steven Jacobson

Chapter 32:

Applications of Nanotechnology in Degenerative Disorders of the Brain

Ayaz M. Khawaja and John D. Heiss

Chapter 33:

Brain–Machine Interface and Rehabilitation

Martin Pham, Alexander Taghva, and Ali R. Rezai

Chapter 34:

Nanobioelectronics for Noninvasive Neuronal Therapy

Evangelia Hondroulis, Jairo Nelson, and Chen-Zhong Li

Chapter 35:

In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles

Thomas Birngruber, Eleonore Fröhlich, Frank Sinner, and Thomas Pieber

Chapter 36:

Nanorobotics for Neurosurgery

Robbin Miranda, Gill Pratt, and Geoffrey S. F. Ling

Chapter 37:

Imaging and Tracking Therapeutic Cells with Nanoparticles

Gang Niu and Joseph A. Frank

Chapter 38:

Micro- and Nanotechnology in Nerve Repair

Ali C. Ravanpay and Michel Kliot

Chapter 39:

Nanotechnology: Applications to Pediatric Neurosurgery

Giancarlo Suffredini and Robert F. Keating

Chapter 40:

Food and Drug Administration Regulatory Framework for Nanodrugs and Nanodevices and the Combination Nanodrug

Vicky Yamamoto, Giancarlo Suffredini, John D. Heiss, David Mishelevich, Grant Palmer, Warren Grundfest, and Babak Kateb

Chapter 41:

Nanoneuroscience and Nanoneurosurgery: A Key Component of President Obama’s Brain Mapping Initiative

Babak Kateb, Vicky Yamamoto, Peter Basser, Michael Roy, Lucien Levy, Jian Tajbakhsh, Gary Steinberg, Allyson Rosen, Keith L. Black, Charlie Teo, Kuldip Sidhu, Mitchel Berger, and Warren Grundfest

About the Editors

Babak Kateb, founding chairman of the board of SBMT and Brain Mapping Foundation, Scientific Director of SBMT, and President of Brain Mapping Foundation, West Hollywood, CA, USA, Director of the National Center for Nano-Bio-Electronics, NASA Research Park, Moffet, CA, USA, Senior Editor of SBMT-NeuroMapping & Therapeutics, Research Scientist, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA, and Visiting Scientist, NASA/Jet Propulsion Laboratory (JPL), Pasadena, CA, USA.

John D. Heiss, chair of the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, and Clinical Professor of Neurosurgery, George Washington University, Washington, DC, USA.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Neurology
MEDICAL / Surgery / Neurosurgery
SCIENCE / Biotechnology
SCIENCE / Life Sciences / Neuroscience