The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders, 1st Edition (Hardback) book cover

The Third Histamine Receptor

Selective Ligands as Potential Therapeutic Agents in CNS Disorders, 1st Edition

Edited by Divya Vohora

CRC Press

406 pages | 12 Color Illus. | 68 B/W Illus.

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pub: 2008-11-14
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Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders

The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon.

The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases.

Presents Several Disease-Specific Chapters

Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.


… this book offers a key overview of the subject, useful not only to mature researchers but also all scientists who discover this field. … will certainly become a work of reference in this rapidly-growing domain.

—Dr. Laurent Provins, UCB Pharma (Belgium), in ChemMedChem 2009

Table of Contents


H3 Receptor Target: Past, Present, and Future

Perspectives from Worldwide H3 Experts, D. Vohora and S. Celanire

The Third Histamine Receptor: From Discovery to Clinics, a Long- Lasting Love Story at INSERM and Bioprojet, J.-C. Schwartz

Histamine as a Neurotransmitter, O. Selbach and H.L. Haas


Phylogeny, Gene Structure, Expression, and Signaling, P. Panula, C. Jin, K. Karlstedt, and R.A. Bakker

Drug Discovery: From Hits to Clinical Candidates, S. Celanire, F. Lebon, and H. Stark

Peripheral Actions and Therapeutic Potential in Periphery, G. Coruzzi and M. Adami


Cognitive Functions, Attention-Deficit Hyperactivity Disorders, and Alzheimer’s Disease, M.B. Passani, P. Blandina, K.E. Browman, and G.B. Fox

Sleep Disorders, J.E. Shelton, T.W. Lovenberg, and C. Dugovic

Obesity, T.A. Esbenshade, M.E. Brune, and M.I. Strakhova

Epilepsy, D. Vohora and K.K. Pillai

Schizophrenia, K.E. Browman, M. Zhang, G.B. Fox, and L.E. Rueter

Other Central Nervous System Disorders, P.L. Chazot and F.C. Shenton

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Anatomy
SCIENCE / Chemistry / General
SCIENCE / Life Sciences / General
SCIENCE / Life Sciences / Neuroscience