1096 Pages 238 B/W Illustrations
    by CRC Press

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    When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on these organisms has been widely available, until now. Filling this void, The Toxicology of Fishes, written by recognized experts, covers toxic responses ranging from reduced reproduction and/or abnormal development, growth, and differentiation.

    General Principles — Discusses fundamental topics such as the bioavailability of chemicals present in the aquatic environment to fishes, processes governing chemical distribution within these organisms, how fish metabolize organic chemicals, and fundamental mechanisms of chemical toxicity

    Key Target Systems and Organismal Effects — Describes key target organ systems for chemical impacts in fish, how chemicals produce cancer in these animals, and how fishes can develop resistance to chemical toxicity

    Methodologies and Applications — Dovers methods for the assessment of chemical effects on fish such as toxicity tests, biomarkers, simulated ecosystems, and modeling approaches and the use of data from such studies in ecological risk assessments

    Case Studies — Provides examples of how the principles and approaches presented in earlier units are actually deployed in studies

    Illustrated by case studies of actual, large-scale field investigations, the book reviews the tools used to assess unwanted effects in laboratory model- and wild fish in detail. With 238 illustrations, 70 tables, and 50 equations, this comprehensive monograph presents detailed information on the boiavailability of chemical pollutants, their distribution, metabolism, and excretion in the host fish and mechanisms and sites of toxic responses.

    General Principles

    Introduction, R.T. Di Giulio and D.E. Hinton
    Bioavailability of Chemical Contaminants in Aquatic Systems, R.J. Erickson, J.W. Nichols, P.M. Cook, and G.T. Ankley
    Toxicokinetics in Fishes, K.M. Kleinow, J.W. Nichols, W.L. Hayton, J.M. McKim, and M.G. Barron
    Biotransformation in Fishes, D. Schlenk, M. Celander, E.P. Gallagher, S. George, M. James, S.W. Kullman, P. van den Hurk, and K. Willett
    Receptor-Mediated Mechanisms of Toxicity, M.E. Hahn and E.V. Hestermann
    Reactive Oxygen Species and Oxidative Stress, R.T. Di Giulio and J.N. Meyer

    Key Target Systems and Organismal Effects

    Liver Toxicity, D.E. Hinton, H. Segner, D.W.T. Au, S.W. Kullman, and R.C. Hardman
    The Osmoregulatory System, S.E. Wendelaar Bonga and R.A.C. Lock
    Toxic Responses of the Fish Nervous System, S.P. Bradbury, R.W. Carlson, T.R. Henry, S. Padilla, and J. Cowden
    The Endocrine System, P. Thomas
    The Immune System of Fish: A Target Organ of Toxicity, E. Carlson and J.T. Zelikoff
    Chemical Carcinogenesis in Fishes, J.M. Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, and G.K. Ostrander
    Toxicity Resistance, P.A. Van Veld and D.E. Nacci

    Methodologies and Applications

    Exposure Assessment and Modeling in the Aquatic Environment, D. Mackay and L. Milford
    Fish Toxicity Studies, G.M. Rand
    Biomarkers, D. Schlenk, R. Handy, S. Steinert, M.H. Depledge, and W. Benson
    Aquatic Ecosystems for Ecotoxicological Research: Considerations in Design Analysis for Fish, T.W. La Point, J.H. Kennedy, J.K. Stanley, and P. Balci
    Ecological Risk Assessment, D.R. Mount and T.R. Henry

    Case Studies

    Mining Impacts on Fish in the Clark Fork River, Montana: A Field Ecotoxicology Case Study, S.N. Luoma, J.N. Moore, A. Farag, T.H. Hillman, D.J. Cain, and M. Hornberger
    Toxicology of Synthetic Pyrethroid Insecticides in Fish: A Case Study, J.R. Coats
    Reproductive Impairment of Great Lakes Lake Trout by Dioxin-Like Chemicals, D.E. Tillitt, P.M. Cook, J.P. Giesy, W. Heideman, and R.E. Peterson
    The Effects of Polycyclic Aromatic Hydrocarbons in Fish from Puget Sound, Washington, L.L. Johnson, M.R. Arkoosh, C.F. Bravo, T.K. Collier, M.M. Krahn, J.P. Meador, M.S. Myers, W.L. Reichert, and J.E. Stein
    Effects of the Exxon Valdez Oil Spill on Pacific Herring in Prince William Sound, Alaska, G.D. Marty
    Case Study: Pulp and Paper Mill Impacts, M.G. Dubé, K.R. Munkittrick, and L.M. Hewitt
    Estrogenic Effects of Treated Sewage Effluent on Fish: Steroids and Surfactants in English Rivers, C.R. Tyler, E.J. Routledge, and R. van Aerle


    Richard T. Di Giulio, David E. Hinton

    "… provides a useful resource for the regulatory toxicologist… well-presented and concise book worthy of a position on the bookshelf of all fish toxicologists…."

    —Jonathan Burke, Covance Laboratories Ltd, UK, in the British Toxicology Society Newsletter