The development of specific antibodies as probes and detectors for adsorbed proteins by Dr. Leo Vroman and co-workers in the 1960s and 1970s confirmed his earlier observations and suspicions that blood protein adsorption involved a hierarchical series of collision, adsorption, and exchange processes. These observations and concepts were confirmed by other scientists and came to be known as 'the Vroman effect'. The core concept of the Vroman effect admits many approaches and over-reaches complex and not fully resolved questions of enzymology, transport phenomena, the statistical mechanics of protein conformation, longrange forces in liquids, and surface physics. This volume contains the presentations from the symposium which was held in honour of the 75th birhday of Dr. Leo Vroman, in Gouda, The Netherlands, and deals with various aspects of the Vroman effect.
Foreword -- photograph Poem -- In Vitro, In Vivo, In Toto L. Vroman Leo Vroman, scientist: An appreciation E.F. Leonard Bibliography of Leo Vroman Why proteins prefer interfaces W. Norde and J. Lyklema Surface exclusion and molecular mobility may explain Vroman effects in protein adsorption G.M. Willems, W.Th. Hermens and H.C. Hemker Vroman effects, techniques and philosophies J.D. Andrade and V. Hlady The effects of temperature and buffer on fibrinogen adsorption from blood plasma to glass S.M. Slack and T.A. Horbertt Measurement of fibronogen adsorption from blood plasma using 125I-fibrinogen and a direct ELISA technique S.M. Slack, S.E. Posso and T.A. Horbett Mechanism of the participation of the contact system in the Vroman effect. Review and summary C.F. Scott 'Lens-on-surface': a versatile method for the investigation of plasma protein exchange reactions on solid surfaces H. Elwing, P. Tengvall, A. Askendal and I. LundstrÃ¶m The Vroman effect in tube geometry: the influence of flow on protein adsorption measurements P. Wojciechowski and J.L. Brash Is the Vroman effect of importance in the interaction of blood with artificial materials E.F. Leonard and L. Vroman Protein adsorption from plasma onto poly(n-alkyl methacrylate) surfaces H.S. van Damme, T. Beugeling, M.T. Ratering and J. Feijen Vessel wall proteins adhesive for platelets J.J. Sixma, G. Hindriks, H. van Breugel, R. Hantgan and P.G. de Groot A comparison of the adsorption of three adhesive proteins to biomaterial surfaces D.J. Fabrizius-Homan and S.L. Cooper Analogies in the two-dimensional spatial arrangement of adsorbed proteins and adhering bacteria: bovine serum albumin and Streptococcus sanguis 12 H.J. Busscher, H.C. van der Mei and J.M. Schakenraad Off into a thinning fog L. Vroman One more world of Leo Vroman A.L. Adams, G. Fischer and P. Munoz