Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.
Table of Contents
Adenovirus Biology and Development as a Gene Delivery Vector.
Leslie A. Nash and Robin J. Parks
Innate and adaptive immune responses to adenovirus.
Svetlana Atasheva and Dmitry M. Shayakhmetov.
Helper-dependent adenoviral vectors for cell and gene therapy.
Nicola Brunetti-Pierri and Philip Ng
Chemical and combined genetic and chemical modifications of adenovirus vector capsids to overcome barriers for in vivo vector delivery.
Design and applications of adenovirus-based hybrid vectors.
Anja Ehrhardt and Wenli Zhang
Adenovirus vectors for genome editing involving engineered endonucleases.
Kamola Saydaminova, Maximilian Richter, Philip Ng, Anja Ehrhardt, André Lieber
Adenoviruses for Vaccination
.Michael A. Barry
Use of oncolytic adenoviruses for cancer therapy.
Cristian Capasso, Manlio Fusciello, Erkko Ylösmäki, Vincenzo Cerullo
Philip Ng is jointly an Associate Professor of Department of Molecular and Human Genetics and the Program in Translational Biology & Molecular Medicine at the Baylor College of Medicine. He is interested in developing gene therapies for genetic diseases using helper-dependent adenoviral vectors (HDAd).
Nicola Brunett-Pieri is an Associate Professor in the Department of Translational Medicine at Federico II University in Naples and an Associate Investigator at Telethon Institute of Genetics and Medicine (TIGEM).