Thermodynamics of Membrane Receptors and Channels synthesizes a wealth of new information regarding the biophysics of membrane proteins. New insights provided by molecular genetics, single channel recording, and high resolution structural techniques are discussed from a conceptual perspective. Basic theoretical topics are introduced, developed, and then extensively illustrated with recent results from the literature or data from the authors' own laboratories. Theoretical and experimental information is incorporated into in-depth discussions of ion permeation mechanisms, ion channel and receptor conformational changes, aggregate activity of complexes of lipids and proteins, and how coupling is achieved between different energy modes in the many transduction systems residing in biomembranes.
Thermodynamics of Membrane Receptors and Channels will be valuable both as a learning aid and a reference for biophysicists, neuroscientists, cell biologists, physiologists, and other researchers investigating any aspects of biomembranes.
Structure and Stability of Membrane Proteins (T. Yeates). Interactions of Ions and Membrane Proteins (P. Jordan). Incorporation of Peptides into Membranes (D. Roise). Thermodynamics of Lipid-Protein Interactions in Lipid Membranes: The Hydrophobic Matching Condition (O. Mouritsen and M. Sperotto). Molecular Crowding and Protein Organization in Biological Membranes (J. Abney and B. Scalettar). The Energetics of Activation of Membrane Receptors (M. Jackson). Activation of Receptors Directly Coupled to Channels (M. Jackson). Activation of Receptors Coupled to G-Proteins and Protein Kinases (M. Jackson). Mechanosensitive Ion Channels: Biophysics and Pharmacology (B. Martinac). Light Energy Transduction in Bacteriorhodopsin (T. Ebrey). Channels Under Osmotic Stress (J. Zimmerberg and A. Parsegian). Fluctuations in Ion Channels (F. Sigworth and S. Heinemann).