It is common knowledge that thromboembolic disease is often the earliest manifestation and almost the most frequent complication of cancer. Recent studies have investigated the mechanisms by which cancer causes thrombosis and have emphasized the importance of the coagulation system in angiogenesis and tumor metastasis. Thrombosis and Cancer offers a detailed and authoritative review of the issues involved in the links between thrombosis, hemostasis, and cancer, an association long documented but still not completely understood.
This text provides comprehensive and timely coverage of the current knowledge of cancer-associated thrombosis, its pathogenesis, clinical features, prevention, and therapy. It specifically addresses the relationship between hemostatic systems and cancer, thus providing a unique and much needed focus. All of the contributors are acknowledged specialists in their fields and have experience conducting large clinical trials in oncology and thrombosis. Their discussions cover all aspects of the topic, from long-term complications to cancer surgery.
With input from specialists in a range of disciplines including hematology, pharmacology, and surgery, this thorough text will be of interest to general practitioners, internists, oncologists, hematologists, and all physicians involved in the management of cancer patients.
Table of Contents
Thrombosis and Cancer: A Short History of the Trousseau's Syndrome, M.H. Prins and H.-M.M.B. Otten
Pathogenesis of Thrombosis in Cancer, A. Falanga, M. Marchetti, and A. Vignoli
Platelets and Cancer, A. Klepfish, A. Schattner, G. Lugassy, and S. Karpatkin
The Role of Blood Clotting in Tumor Metastasis: A Case for Tissue Factor, M.B. Donati and R. Lorenzet
The Fibrinolytic System in Cancer, G. Lugassy and A. Klepfish
Tumor Angiogenesis and Blood Coagulation, P.M. Fernandez, S.R. Patierno, and F.R. Rickles
Risk of Cancer in Patients Presenting with Venous Thromboembolism, A. Piccioli and P. Prandoni
Thrombotic Complications of Overt Cancer, G. Lugassy and B. Yoffe
Systematic Microangiopathies in the Cancer Patient, M. Levi
Thrombophilia and Risk of Venous THromboembolism in Cancer, R. Hoffman and B. Brenner
Long-Term Thrombotic Complications in Cancer-Treated Patients: The Problem of Recurrent Venous Thromboembolism, G.F. Pineo and R.D. Hull
Prevention of Cancer-associated Thrombosis: An Overview, M. Levine
Thromboprophylaxis in Cancer Surgery, A.K. Kakkar and G.A. Pertralia
Catheter-related Arm-Vein Thrombosis in Patients with Cancer, M. Monreal
Prevention and Treatment of Thrombosis in Cancer Patients, H.K. Breddin and R. Bauersachs
Antimalignant Properties of Antithrombotic Agents, C.P.W. Klerk, S.M. Smorenburg, and H.R. Buller
'...a well-written multiauthored book that will fulfil its stated purpose - "to provide comprehensive and timely coverage of our current knowledge of cancer-associated thrombosis". It will be of interest to clinicians in many disciplines.' - The New England Journal of Medicine