Thrombospondin represents the most extensive compilation of knowledge on this important protein. Leading scientists from around the world cover such topics as the structure of the protein; its sequence and homologies with other proteins; its chemistry; and its involvement in protein interactions, cell interactions, and systemic functions. The book discusses the contribution of thrombospondin to processes such as morphogenesis, metastasis, hemostasis, and malaria infection. Information regarding thrombospondin's cell receptor and future directions of research are also considered. Thrombospondin will be an important reference for hematologists, cell biologists, developmental biologists, biochemists, artificial organ engineers, and others interested in this vital protein.
The Structure of Thrombospondin (J. Lawler and T.C. Detwiller). The Distribution of Thrombospondin (J. Lahav and P. Clezardin). Interactions of Thrombospondin with Macromolecules (J. Lahav and D.D. Roberts). Interactions of Thrombospondin with Cells (W.A. Frazier, C.A. Prater, D. Jaye, M.D. Kosfeld, J.L. McGregor, and H. Boukerche). Thrombospondin in Physiological Systems (K.S. O'Shea, D.A. Walz, R.S. Zafar, Z. Zeng, R.L. Silverstein, and S.J. Suchard). Thrombospondin in Pathophysiology (B. Kehrel, E. Flicker, G.P. Tuszynski, and J.A. Sherwood). The Putative Receptors for Thrombospondin (D.F. Mosher, X. Sun, A.S. Asch, and J. Lawler).