1st Edition

Tissue Engineering and Regenerative Medicine A Nano Approach

    592 Pages 242 Color Illustrations
    by CRC Press

    Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends.

    Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas:

    • Nanobiomaterials and scaffolds—including nanocomposites and electrospun nanofibers
    • Tissue mechanics
    • Stem cells and nanobiomaterials
    • Oral and cranial implants and regeneration of bone
    • Cartilage tissue engineering
    • Controlled release—DNA, RNA, and protein delivery
    • Animal science and clinical medicine

    The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications.

    Biostable Composite Biomaterials in Medical Applications
    Pekka K. Vallittu

    Bioceramic and Biopolymer Nanocomposite Materials for Use in Orthopedic Applications
    Clark E. Barrett, Ruth E. Cameron, and Serena M. Best

    Tailoring of Bioactive Glasses
    Leena Hupa

    Bioactive Ceramic Coatings for Metallic Implants
    Niko Moritz, Paula Linderbäck, and Timo O. Närhi

    Induction of Bone Formation by Calcium Phosphate-Based Biomimetic Macroporous Constructs
    Ugo Ripamonti

    Bioinspired Titanium Implants: The Concavity—The Shape of Life
    Ugo Ripamonti, Louise Renton, and Jean-Claude Petit

    Bioactive Surface Modifications for Dental and Orthopedic Implants
    Ivan Donati, Eleonora Marsich, Andrea Travan, and Sergio Paoletti

    Oral Implants: Biological Background and Current Concepts in Peri-Implantitis Treatment
    Nicola U. Zitzmann and Tuomas Waltimo

    Soft Tissue Attachment on Implant Surface
    Timo O. Närhi

    Surface Chemical Determination of the Placement, Growth, and Differentiation of Cells for Drug Screening, Toxin Detection, and Lab-on-a- Chip Applications
    Peter Molnar, Murugan Ramalingam, and James J. Hickman

    Electrospun Nanofibers as Next-Generation Bioactive Tissue Scaffolds
    Victor Leung, Ryan Hartwell, Elodie Faure, Heejae Yang,Aziz Ghahary, and Frank Ko

    Mechanics of Fiber-Reinforced Scaffolds and Tissues Formed from Organized Electrospun Assemblies
    Matthew B. Fisher and Robert L. Mauck

    Regulation of Stem Cell Behavior Using Nanobiomaterials
    Andrew M. Handorf, Patrick T. Brown, John G. Barber, andWan-Ju Li

    Biomaterials and Their Use in Craniofacial Surgery
    Kurt Laedrach

    Nanobiomaterials for Bone Tissue Engineering
    Meng Deng, Roshan James, Cato T. Laurencin, andSangamesh G. Kumbar

    Stem Cells, Growth Factors, and Biomaterials in Bone Surgery
    George K. B. Sándor

    Nanomaterials for Cartilage Regeneration
    Shirley Keolebogile Motaung and A. Hari Reddi

    Cartilage Tissue Engineering: Advances in Stem Cell-Based Approaches
    Sibylle Grad, Martin J. Stoddart, David Eglin, and Mauro Alini

    Stem Cells and Nanobiomaterials for Cardiac Tissue Regeneration
    Debasish Mondal

    Nanotechnology for Engineering Cellular Microenvironment and Gene Delivery
    Janice H. Lai, Anusuya Ramasubramanian,Shaheen Jeeawoody, and Fan Yang

    Nanobiomaterial-Based Short Interfering RNA Delivery Systems
    Yoon N. Cho, Murugan Ramalingam, and Ziyad S. Haidar

    Sugar–Glass Nanoparticles for Protein Delivery
    Jyotsnendu Giri and Marcus T. Cicerone

    Clinical Relevance of Tissue Engineering
    Koteshwar N. Sridhar and Daniel G. Miller

    Future Perspectives of Biomaterials and Stem Cells in Regenerative Medicine
    Dilip Dey



    Murugan Ramalingam is an associate professor and scientist ‘G’ at the Centre for Stem Cell Research (CSCR), Department of Biotechnology, Government of India, Christian Medical College Bagayam Campus, Vellore, Tamil Nadu, India. He is also an adjunct associate professor at the Tohoku University, Sendai, Miyagi, Japan. Dr. Ramalingam’s current research interests focus on the development of multiphase biomaterials, through conventional to nanotechnology to biomimetic approaches, cell patterning, stem cell differentiation, and tissue engineering. He is the author of more than 125 publications, including peer-reviewed journal papers, conference proceedings, book chapters, authored books, edited books, and patents relevant to biomaterials and tissue engineering. He serves on the editorial boards of multiple biomaterials- and tissue engineering-related journals.

    Pekka Vallittu is a full professor of biomaterials science in the Faculty of Medicine, University of Turku, Finland, and works as the dean of the Institute of Dentistry and the director of the Turku Clinical Biomaterials Centre. He is also an honorary professor at the University of Hong Kong, Pokfulam. Professor Vallittu’s research activity on fiber-reinforced composites started from his hobby of model aircraft and has lasted for more than 25 years. His first applications for fiber-reinforced composites were in dentistry, followed by active research to utilize fiber-reinforced composites as biomimetic materials, also in medicine. Professor Vallittu has more than 300 original research papers, 500 other papers and abstracts, and 140 granted international patents based on 17 innovations. He has been awarded a Distinguished Scientist Award in Prosthodontics and Implant Research by the International Association of Dental Research.

    Ugo Ripamonti is a professor and the director of the Bone Research Laboratory, a research unit of the South African Medical Research Council and the University of the Witwatersrand, Johannesburg, South Africa, within the Faculty of Health Sciences at the medical school. Dr. Ripamonti is a national and an international scholar focusing on experimentation on tissue engineering of bone, tissue induction, and morphogenesis by transforming growth factor-βs and osteoinductive biomimetic matrices in preclinical and clinical contexts. He has received numerous awards, including the Marshall R. Urist Awarded Lecture at the Sixth International Conference on Bone Morphogenetic Proteins in 2006 in Dubrovnik. He has published more than 200 scientific papers, including patents and book chapters for specialists.

    Wan-Ju Li is the principal investigator of the Musculoskeletal Biology and Regenerative Medicine Laboratory at the University of Wisconsin-Madison. He is also an affiliated faculty member in the Cellular and Molecular Biology Program, Stem Cell and Regenerative Medicine Center. Professor Li’s research interests include stem cell, tissue engineering, nanobiomaterial, and skeletal biology. He has received the Fellow Award for Research Excellence from the National Institutes of Health and the Young Investigator Research Award from the North American Spine Society. Professor Li has published 30 papers, nine book chapters, and more than 60 abstracts. He holds three patents in cartilage, intervertebral disc, and tendon/ligament applications. He also serves in the editorial board of the American Journal of Stem Cells, the Journal of Regenerative Medicine and Tissue Engineering, the Formosan Journal of Musculoskeletal Disorders, and the Journal of Biosensors and Bioelectronics.

    "This book broadly covers current topics of tissue engineering. In particular, it would be helpful for those who are studying in this field based on nanotechnology and biomaterial science."
    —Shoji Takeuchi, The University of Tokyo