Tobacco Smoke Exposure Biomarkers: 1st Edition (Hardback) book cover

Tobacco Smoke Exposure Biomarkers

1st Edition

By Qingyuan Hu, Hongwei Hou

CRC Press

288 pages | 29 B/W Illus.

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pub: 2015-04-01
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Description

Written by experts in the analytical chemistry of tobacco smoke, Tobacco Smoke Exposure Biomarkers summarizes the toxicology, metabolic pathway, and biomarkers of nicotine, TSNAs, PAHs, VOCs, AAs, Catechol and Hydroquinone, HCN, CO and NOx, and heavy metals, and the use of this biomarker in exposure assessment and/or cigarette smoke exposure environmental epidemiology.

A convenient one-stop guide, the book brings together information on some exposure biomarkers and nicotine addiction in humans with regulatory implications and strategies. The authors also include discussions of how smoke exposure biomarkers may be used to shape regulation and health policy. Ethics guidelines, details of method development, and the validated relative bioanalytical method provided in the appendixes rounds out the coverage. The book gives you tools to further research biomarkers for tobacco carcinogens and to face emerging health challenges such as delivery of nicotine via electronic cigarettes.

Table of Contents

Smoking and Health

Global Tobacco Epidemic

Smoke-Related Diseases

Smoke Constituents of Concern

Biomarkers

Biomarkers of Exposure to Environmental Tobacco Smoke

Biomarkers Application in Tobacco Regulation and Healthy Policy

References

Biomonitoring and Biomarkers

Introduction

Preparation of Samples of Biological Materials

Methodology of Determination of Biomarkers

Biomarkers in Tissues and Body Fluids

Conclusions

References

Biomarkers of Pyridine Alkaloids: Nicotine and Cotinine

Introduction

Toxicological Evaluation

Metabolic Pathway of Nicotine in the Body

Samples Used

Analytical Technology

Metabolites of Nicotine

Application of Nicotine Biomarkers on Biomonitor

References

Biomarkers of Tobacco-Specific Nitrosamines

Introduction

NNK

N-Nitrosonornicotine

TSNA Biomarkers in Others

References

Biomarkers of Polycyclic Aromatic Hydrocarbons

Introduction

PAHs and PAH Exposure and Carcinogenesis

Enzymes of Metabolic Activation and Detoxication of PAHs

Biomonitoring PAH and Their Metabolites in Human Urine

PAH Biomarkers in Others

Discussion

Conclusion

References

Biomarkers of Volatile Organic Compounds

Introduction

Toxicological Evaluation

Metabolic Pathway in the Body

Discussion

Conclusion

References

Aromatic Amines

Introduction

ABP

NA

Discussion

Conclusion

References

Biomarkers of Catechol and Hydroquinone

Introduction

Toxicological Evaluation

Biodegradation and Metabolism

Biomarkers of Hydroquinone and Catechol

References

Biomarkers of HCN, CO, and NOx Exposure

Introduction

Hydrogen Cyanide (HCN)

Carbon Monoxide (CO)

Nitrogen Oxides

Discussion

Conclusion

References

Biomarkers of Heavy Metal Exposure

Introduction

Metabolism Pathway

Cadmium

Arsenic

Mercury

Lead

Discussion

Conclusion

References

Application of Smoke Exposure Biomarker in Epidemiologic Research

Smoke Exposure Biomarker and Health Effects

Application of Smoke Exposure Biomarker in Epidemiologic Research

References

Suggestions for the Use of Specific Biomarkers of Exposure to Cigarette Smoke for Regulation Purposes

Background

Measuring Exposure

Measuring Biological Changes

Measuring Injury and Disease

Recommended Uses for Biomarkers of Exposure and Effect

Measuring Reduced Injury or Harm

Summary of Biomarker Recommendations

A: Guideline Document for Ethics Review Concerning Research Involving Intervention on Humans by the European Commission

B: Declaration of Helsinki (V2008)

Protection of Animals Used for Scientific Purposes

Guidance for Industry-Bioanalytical Method Validation by the Food and Drug Administration

E: Toxicity and IARC Classification of Targeted Constitutes

About the Authors

Dr Qingyuan Hu is the sole representative of the People’s Republic of China to the above mentioned working group. He has attended every Conference of the Parties to WHO/FCTC, from the First Session held in Geneva in 2006. At the Fourth Session, held in Punta del Este in 2010, the Guidelines for Implementation of WHO/FCTC articles 9 and 10 were adopted as "Partial" and "Provisional", as a number of sections were left "intentionally blank", for completion as evidence on tobacco product characteristics including smoke biomarker is generated step-by-step. At the Fifth Session, held in Seoul in 2012, a Background Analysis on addictiveness was presented, which Dr Hu made significant and substantial scientific contributions to.

Dr Hu is also the sole representative of the People’s Republic of China to the WHO Tobacco Laboratory Network (TobLabNet), which comprises 25 laboratories around the world including the US Centers for Disease Control and Prevention (CDC) and the US National Cancer Institute (NCI), both founding members of TobLabNet. Among other tasks, TobLabNet

Finally, Dr Hu is also the sole representative of the People’s Republic of China to the Study Group on Tobacco Product Regulation (TobReg). TobReg is the designated scientific advisory body to WHO on all matters concerning tobacco smoke biomarker.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED078000
MEDICAL / Public Health
MED096000
MEDICAL / Toxicology