Toxicologic Pathology: Nonclinical Safety Assessment, 1st Edition (e-Book) book cover

Toxicologic Pathology

Nonclinical Safety Assessment, 1st Edition

Edited by Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath

CRC Press

1,015 pages

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pub: 2017-10-23
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pub: 2013-04-09
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Description

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Saf

Table of Contents

Concepts in Drug Development: Overview of Drug Development; Nonclinical Safety Evaluation of Drugs; Toxicokinetics and Drug Disposition; Introduction to Toxicologic Pathology; Routine and Special Techniques in Toxicologic Pathology; Principles of Clinical Pathology; Toxicogenomics in Toxicologic Pathology; and Spontaneous Lesions in Control Animals Used in Toxicity Studies. Organ Systems: Gastrointestinal Tract; Liver, Gallbladder, and Exocrine Pancreas; Respiratory System; Urinary System; Hematopoietic System; Lymphoid System; Bone, Muscle, and Tooth; Cardiovascular System; Endocrine Glands; Reproductive System and Mammary Gland; Skin; Nervous System; and Special Senses: Eye and Ear.

About the Editors

Pritam S. Sahota is the Executive Director of Special Projects Pathology at the Novartis Institutes for Biomedical Research in East Hanover, New Jersey, USA.

James A. Popp is with Stratoxon LLC in Lancaster, Pennsylvania, USA. Jerry F. Hardisty is with Experimental Pathology Laboratories in Sterling, Virginia.

Chirukandath Gopinath is an Independent Consultant in Toxicology/Pathology in Cambridgeshire, UK.

Subject Categories

BISAC Subject Codes/Headings:
MED067000
MEDICAL / Pathology
MED071000
MEDICAL / Pharmacology
MED096000
MEDICAL / Toxicology