Toxicological Risk Assessment : Biological and Statistical Criteria book cover
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Toxicological Risk Assessment
Biological and Statistical Criteria




ISBN 9780367258009
Published August 27, 2019 by CRC Press
244 Pages

 
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Book Description

First Published in 1986, this two-volume set explores the methods of toxicological risk assessment. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for toxicologists and other practitioners in their respective fields.

Table of Contents

Volume I.

SECTION A – BIOLOGICAL CRITERIA.

1. Interspecies Exploration of Drug and Genetic Toxicity Data.  2. Pharmacokinetic Differences Between Species.  3. Differences in Metabolism at Different Dose Levels.  4. Toxicological Effects on Carcinogenesis.  5. Problems in Interspecies Exploration.

SECTION B – STATISTICAL CRITERIA.

6. Statistical Design and Analysis of the Long-Term Carcinogenicity Bioassay.  7. Statistical Analysis of Rodent Tumorigenicity Experiments.  8. Use of the Hartley-Sielken Model in Low-Dose Extrapolation.  9. A Review of Methods for Calculating Statistical Confidence Limits in Low-Dose Extrapolation.  10. Incorporation of Pharmacokinetics in Low-Dose Risk Estimation.  Index.

Volume II.

SECTION A – GENERAL CRITERIA.

1. Epidemiological Methods for the Assessment of Human Cancer at Risk.  2. Assessment of Human Exposure to Environmental Contaminants with Special Reference.  3. The Influence of Nutrition, Immunologic Status, and Other Factors on the Development of Cancer.  4. The Significance of Benefits in Regulatory Decision Making.  5. Measuring Health Benefits.  6. Food Safety Regulations.

SECTION B – CASE STUDIES

7. Case Study – Asbestos.  8. Vinyl Chloride – A Cancer Case Study.  9. An Integrated Approach to the Study of Formaldehyde Carcinogenicity in Rats and Mice.  10. Determination of Human Risk in Regulating Polychlorinated Biphenyls (PCBs) – A Case Study.  11. Saccharin – A Bitter Sweet Case.  Index.

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Author(s)

Biography

D. B. Clayson, D. Krewski, I. Munro