Toxicology is an integral part of the risk assessment process.
In this book, investigators from the scientific and regulatory communities describe recent technical developments in risk assessment embracing toxicology and its allied sciences, risk qualification and characterisation, risk management, and risk communication.
Case studies pertaining to current issues involving chemical and environmental risks, including military and industrial scenarios, are presented.
Chapters describe value and ethical choices underlying toxicological decisions, economic and legal implications of regulations, understanding risk, and recommendations of the commission on risk assessment and risk management.
Preface; 1. A Window of Opportunity for Toxicology; 2. The Evolving Principles of Risk Analysis; 3. How to Communicate Risk in a Low Trust/High Concern Environment; 4. Values and Ethical Choices that Underlie Toxicologic and Risk-Analysis Decisions; 5. Improving the Risk Assessment Process; 6. Improving Risk Characterization at the US Environmental Protection Agency; 7. Multiple Factors in Risk Assessment; 8. Environmental Factors Modifying Sensitivity to Chemicals; 9. Animal Model of Chemical Sensitivity Involving Cholinergic Agents; 10. Application of Chemical Hormesis Concept to Risk Assessment: Reproductive Toxicity as an Example; 11. Trends in Toxicology Modeling for Risk Assessment; 12. Overview of Environmental Decision-Support Software; 13. Application of Risk-Assessment Techniques to Military Deployments: Operation Desert Storm, Operation Joint Endeavor, Operation Desert Focus; 14. Application of Risk-Assessment Techniques to Military Scenarios: Multipathway Exposure Assessment for Chemical Agent Incinerators; 15. A Drinking Water Advisory: Consumer Acceptability Advice and Health Effects Analysis on Methyl Tertiary-Butyl Ether; 16. Arsenic: Moving Toward a Regulation; 17. The Evolution of Health-Risk Assessment: Trichloroethylene as a Case Study; 18. History of Methylene Chloride in Consumer Products: Tracing Scientific Knowledge, Regulations, and Perceptions; 19. Risk Assessment and Risk Management in Regulatory Decision Making: Recommendations of the Commission on Risk Assessment and Risk Management; 20. Risk Assessment and Risk Management: Pathways Toward Process Enhancement