Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
Preface.Ligandin and Glutathione S-Transferases; Historical Milestones. Families of Glutathione Transferases.Mammalian Glutathione S-Transferase Genes: Structure and Regulation. Combinatorial Protein Chemistry In Three Dimensions: A Paradigm For The Evolution Of Glutathione Transferases With Novel Activities. Substrates and Reaction Mechanisms of GSTs. Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides. GST Polymorphism: Where To Now? Clinical Applications and Functional Analysis. Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development.Physiological Substrates of Glutathione S-Transferases. Glutathione S-transferases as modulators of signal transduction. Glutathione-conjugate transport and Stress-Response Signaling: Role of RLIP76. Glutathione-S-Transferases and Oxidative Injury of Cardiovascular Tissues. Mitochondrial Glutathione S-Transferase Pool in Health and Disease. Activation of Microsomal Glutathione Transferase 1 in Toxicology. Glutathione S-transferase Isozyme Composition of Human Tissues. Enzymology of glutathione S-transferases: Laboratory Methods.