375 pages | 83 B/W Illus.
Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in all areas of GST research and have actively contributed to the progress of this field, the book describes the role of GSTs in toxicology, focusing on their pharmacologic and physiologic roles and their relevance to biological toxicology.
The book provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance. It also covers the physiological significance and the mechanisms of activation of microsomal GSTs. These topics, along with the role of GSTs in detoxification of chemical carcinogens and possible implications of GST polymorphism in human health and disease, make the volume useful to researchers in the field of pharmacology and toxicology.
Chapters cover the possible and exciting role of GSTs in defense mechanisms against chronic oxidative stress-linked disorders such as atherosclerosis and the newly emerging area of GST-mediated modulation of stress-signaling through its catalytic as well as binding activities. They explore an intriguing hypothesis that strongly suggests an important role of the factors that modulate the GSH-electrophile conjugate (GS-E) homeostasis in the regulation of cellular processes. Chapters on known and potential endogenous electrophilic substrates and a major role of GSTs in suppressing stress-induced lipid peroxidation reinforce this newly emerging role of GSTs. These are just a few of the features that make the book helpful to clinicians involved in basic as well as translational research, particularly those studying oxidative stress-related degenerative diseases.
“ Each chapter is well-referenced … The text is illustrated with numerous helpful figures. … the book provides a comprehensive and reasonably detailed review of current knowledge of GST which should provide a useful entry-point to those wishing to gain a deeper understanding of the enzymes and their involvement in cellular functions. … it should also be an invaluable resource to those seeking to continue in the line of Arias, Chasseaud et al and contribute to the body knowledge on these enzymes.”
— Michael Hall, Huntingdon Life Sciences Ltd, UK, in bts – The British Toxicology Society, Issue 30, Summer 2007
Ligandin and Glutathione S-Transferases: Historical Milestones, I. Listowsky and I.M. Arias
Families of Glutathione Transferases, P. Zimniak and S.P. Singh
Mammalian Glutathione S-Transferase Genes: Structure and Regulation, I.R. Jowsey and J.D. Hayes
Combinatorial Protein Chemistry in Three Dimensions: A Paradigm for the Evolution of Glutathione Transferases with Novel Activities, Y. Ivarsson and B. Mannervik
Substrates and Reaction Mechanisms of GSTs, P. Zimniak
Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides, H. Xiao and S.V. Singh
GST Polymorphism: Where to Now? Clinical Applications and Functional Analysis, S.L. Holley, A.A. Fryer, W. Carroll, P.R. Hoban, and R.C. Strange
Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development, V.J. Findlay, D.M. Townsend, and K.D. Tew
Physiological Substrates of Glutathione S-Transferases, R. Sharma, G.A. Shakeel Ansari, and Y.C. Awasthi
Glutathione S-Transferases as Modulators of Signal Transduction, Y. Yang and Y.C. Awasthi
Glutathione-Conjugate Transport and Stress-Response Signaling: Role of RLIP76, S.S. Singhal and S. Awasthi
Glutathione S-Transferases and Oxidative Injury of Cardiovascular Tissues, Y. Yang and P.J. Boor
Mitochondrial Glutathione S-Transferase Pool in Health and Disease, H. Raza and N.G. Avadhani
Activation of Microsomal Glutathione Transferase 1 in Toxicology, M. Shimoji, Y. Aniya, and R. Morgenstern
Glutathione S-Transferase Isozyme Composition of Human Tissues, S. Dhanani and Y.C. Awasthi
Enzymology of Glutathione S-Transferases: Laboratory Methods, S.S. Singhal, K. Drake, S. Yadav, J. Singhal, and S. Awasthi Index