Toxicology of the Kidney: 3rd Edition (Hardback) book cover

Toxicology of the Kidney

3rd Edition

Edited by Joan B. Tarloff, Lawrence H. Lash

CRC Press

1,200 pages | 143 B/W Illus.

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pub: 2004-12-28
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The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney.

The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes.

This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.

Table of Contents


Anatomy and Physiology, J.M. Sands and J. Verlander

Molecular and Cell Biology of Diseased Kidney, L.H. Lash and J.B. Tarloff

Functional Assessment of the Kidney, L.B, Kinter and S.G. Emiegh

In Vitro Techniques in Screening and Mechanistic Studies: Organ Perfusion, Slices, Nephron Components, D.S. Kilpatrick and A.J. Gandolfi

In Vitro Techniques in Screening and Mechanistic Studies: Cell Culture, Cell-free Systems, Molecular/Cell Biology, S.M. Ford


Role of Xenobiotic Metabolism, G.O. Rankin and M.A. Valentovie

Mechanisms of Renal Cell Death, J.F. Harriman and R.G. Schnellmann

Signal Transduction in Renal Cell Repair and Regeneration, B. van de Water and M. de Graauw

Models of Chemically Induced Renal Carcinogenesis, T.J. Monks and S. Lau

The Role of Endocytosis in Nephrotoxicity, D.P. Sundin and B.A. Molitoris

The Role of Cellular Energetics in Nephrotoxicity, L.H. Lash

Adhesion Molecules in Renal Physiology and Pathology, A.R. Parrish

Oxidant Mechanisms in Toxic Acute Renal Failure, A.G. Basnakian, G.P. Kaushal, N. Ueda, and S.V. Shah

Vasoactive and Inflammatory Substances, G. Remuzzi


Renal Syndromes Due to Drugs and Chemicals: Clinical Expression of Nephrotoxity, M.E. De Broe

Antibiotic Nephrotoxicity, P.M. Tulkens

Nephrotoxicity of Cyclosporine, Tacrolimus, and Other Immunosuppressive Immunotherapeutic Agents, L.C. Racusen

Cisplatin-Induced Nephrotoxicity, R. Benegio and W. Lieberthal

The Pathogenesis and Prevention of Radiocontrast-Induced Renal Dysfunction, N. Kaperonis, M. Krause, and G.L. Bakris

Analgesics: Acute and Chronic Effects, J.B. Tarloff

Myocotoxins Affecting the Kidney, E. O'Brien and D.R. Dietrich

Heavy Metals, R.K. Zalups and G.L. Diamond

Chemical-Induced Nephrotoxicity Mediated by Glutathione S-Conjugate Formation, W. Dekant


The Role of Epidemiology in Human Nephrotoxicity, M.R.E. McCredie and J.H. Steward

Age, Sex, and Species Differences in Nephrotoxic Response, R.S. Sellers

Risk Assessment Nephrotoxic Metals, G.L. Diamond

Risk Assessment for Selected Therapeutics, K.N.M. Khan

About the Series

Target Organ Toxicology Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nephrology
MEDICAL / Toxicology