Toxicology of the Nose and Upper Airways: 1st Edition (Hardback) book cover

Toxicology of the Nose and Upper Airways

1st Edition

Edited by John B. Morris, Dennis J. Shusterman

CRC Press

450 pages | 50 B/W Illus.

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Hardback: 9781420081879
pub: 2010-02-19
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Description

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume:

  • Examines the effect of selected pollutants on the upper airways of both humans and experimental animals—emphasizing mechanistic issues in the process
  • Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches
  • Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics

This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

Table of Contents

 

STRUCTURE & FUNCTION IN THE UPPER AIRWAY

1. Functional anatomy of the upper airway in experimental animals

James Wagner, Michigan State University

2. Functional anatomy of the upper airway in humans

Fuad M. Baroody, University of Chicago

3. Functional neuroanatomy of the upper airway in experimental animals

Wayne L. Silver & Paige Roe, Wake Forest University; C.J. Saunders, Univ. of Colorado

4. Functional neuroanatomy of the human upper airway

Murugan Ravindran, Samantha Jean Merck & James N. Baraniuk, Georgetown University

5. Mucosal enzymology of the upper airway

John B. Morris, Univ. of Connecticut & Dennis Shusterman, Univ. of Calif., San Francisco

DOSIMETRY & TOXICOKINETICS OF NASAL EXPOSURE

6. Upper airway dosimetry of gases, vapors and particulate matter in experimental animals

Julia Kimbell & Bahman Asgharian, Hamner Institutes

7. Upper airway dosimetry of gases and vapors in humans

Karla Thrall, Pacific NW Laboratory

8. Upper airway dosimetry of particulate matter in humans

Owen Moss, Hamner Institutes

FUNCTIONAL & PATHOLOGIC RESPONSES AND THEIR MEASUREMENT

9. Exposure and recording systems in human studies

Thomas Hummel, U. Of Dresden & Dennis Shusterman, Univ. of California, San Francisco

10. Biomarkers of nasal toxicity in experimental animals

Mary Beth Genter, University of Cincinnati

11. Biomarkers of nasal toxicity in humans

T.I. Fortoul, C.I. Falcón-Rodríguez, V. Rodríguez-Lara, N. López-Valdez, L.F. Montaño, M.C. Ávila-Casado & P. Mussali-Galante, National University of Mexico

12. Nasal reflexes - including alterations in respiratory behavior - in experimental animals.

John Morris, University of Connecticut

13. Nasal chemoensory irritation in humans

J Enrique Cometto-Muñiz & William S. Cain, University of Calif., San Diego; Michael H. Abraham, Ricardo Sánchez-Moreno & Javier Gil-Lostes, University College, London

14. Nasal reflexes in humans

Kathryn Sowerwine, Samantha Jean Merck & James Baraniuk, Georgetown University

15. Olfactory toxicity in humans and experimental animals

Pamela Dalton, Monell Chemical Senses Center

16. Inflammatory conditions of the nose and paranasal sinuses in experimental animals

Jack Harkema, Michigan State University

17. Inflammatory conditions of the nose and paranasal sinuses in humans

Ricardo Tan & Jonathan Corren, University of California, Los Angeles

18. Chronic tissue changes and carcinogenesis in the upper airway

Ruud Woutersen, TNO (Netherlands)

RESPONSES TO SPECIFIC AGENTS

19. Second hand tobacco smoke exposure in humans

Suzaynn Schick & Dennis Shusterman, University of California, San Francisco

20. Chlorine exposure in humans and experimental animals

Dennis Shusterman, Univ. of Calif., San Francisco & John B. Morris, Univ. of Connecticut

21. Hydrogen sulfide exposure in experimental animals

David Dorman and Melanie Struve, North Carolina State University

22. Sulfur dioxide exposure in humans

Jane Q. Koenig, University of Washington

23. Exposure to volatile organic compounds in humans

Christoph van Thriel, IFADO, Dortmund, Germany

RISK ASSESSMENT AND SPECIAL TOPICS

24. Benchmark dose and noncancer risk assessment for the upper airways

Bruce Winder, Karen Riveles & Andrew Salmon, California Environmental Protection Agency

25. Physico-chemical modeling of sensory irritation in humans and experimental animals

Michael H. Abraham, Ricardo Sánchez-Moreno & Javier Gil-Lostes - University College, London; J. Enrique Cometto-Muñiz & William S. Cain – University of Calif., San Diego

26. Effect of allergic inflammation on irritant responsiveness in the upper airways

Thomas E. Taylor-Clark & Bradley J. Undem, Johns Hopkins Medical School

27. Effect of air pollutants on allergic upper airway disease

Dennis Shusterman, Univ. of California, San Francisco

About the Editors

John B. Morris is Professor and Head of Pharmaceutical Sciences and Assistant Dean for Research at the University of Connecticut. He received his Ph.D. in Toxicology at the University of Rochester in 1979 and carried out a Postdoctoral fellowship in Inhalation Toxicology at New York University. In 1981 he joined the faculty at the University of Connecticut. Dr Morris has authored over 70 peer-review articles and book chapters. He is currently on the editorial board of Inhalation Toxicology.

Dennis J. Shusterman is Professor of Clinical Medicine, Emeritus at the University of California, San Francisco (UCSF). He received his M.D. from University of California, Davis in 1978, and M.P.H. from University of California, Berkley in 1982. He currently serves as a Section Chief within the Occupational Health Branch of the California Department of Public Health, and is an attending physician in the Occupational and Environmental Medicine Clinic at UCSF. He is the author of over 70 peer-reviewed publications in the field of inhalation toxicology and occupational and environmental medicine.

About the Series

Target Organ Toxicology Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
MED079000
MEDICAL / Pulmonary & Thoracic Medicine
MED096000
MEDICAL / Toxicology