The increased incidence of pancreatic cancer in the Western world and its grave prognosis has resulted in an urgency for research in this area. Until now the available data on toxicology of the pancreas has been few and fragmentary, scattered throughout the literature. A benchmark volume, Toxicology of the Pancreas pulls together information in this neglected area of toxicological research and highlights fundamental research performed in the last ten years.
Leaders in the field discuss important structures, the detoxification and toxification process at the cellular and sub-cellular level, the distribution of phase 1 and phase 2 drug-metabolizing enzymes and their role in pancreatic disease, and the role of diet and toxicants on pancreatic disease. The book also covers the role of altered genes in the integrity of the pancreas and explores comparative toxicology in humans and in the lab species used in testing.
Illustrated with histological, electron microscopical, and immunohistochemical formats, this book provides a comprehensive and novel presentation of biological and toxicological data. It stands alone as a reliable resource of information easily accessible to professionals in different disciplines.
Table of Contents
Developmental Biology of the Vertebrate Pancreas. Gross Anatomy of the Pancreas. Fine Structure of the Pancreas, Vascular Anatomy of the Pancreas. Centroacinar Cells - A Neglected Essential Element of the Pancreas. Physiology of Exocrine Pancreas. Drug-Metabolizing Enzymes in the Human Pancreas. Drug-Metabolizing Enzymes in the Pancreas of Animals. Pancreatic Exocrine-Endocrine Interaction. Nutritional Requirements of the Pancreas. Activity of Pancreatic Secretory Trypsin Inhibitor Is Essential against Pancreatotoxic Factors. Pathological Perspectives of Pancreatic Mucins. Growth Factors in Pancreatic Diseases. Toxicology of Natural Hormones and Hormonelike Chemicals. Alcohol and Pancreatitis. Chronic Pancreatitis: the Initial Tissue Damage and the Resulting Fibrosis Patterns. Chemically Induced Exocrine Degeneration, Atrophy, and Arterial Diseases in Rats. Chronic Pancreatic Toxicity - Role of Stem Cells in the Conversion of Pancreas to Liver. Environmental Factors and Exocrine Pancreatic Disease. Environmental Determinants of Exocrine Pancreatic Cancer. The Effects of Nutrients on Pancreatic Malignancy: Part II - Experimental Studies. Toxicity of Tobacco-Specific N-Nitrosamines. Role of Genetic Factors in Inflammatory Diseases of the Pancreas. Genetic Disorders Associated with Exocrine and Endocrine Pancreatic Tumors. Cystic Fibrosis of the Pancreas - the Disease and Its Manifestations. Toxicology of the Endocrine Pancreas. Alterations of the Endocrine Pancreas. Pancreatic Cancer and Diabetes - Cellular Origin of Adeonocarcinoma. Index.
Parviz M. Pour