Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells,a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism.
Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.
Section A: Basic Machinery of Transcription 1. RNA polymerase II transcription machinery 2. Regulatory transcription factors and cis-regulatory regions 3. Chromatin structure and regulation of transcription 4. DNA binding by transcription factors Section B: Cell Regulatory Systems 5. Regulation of transcription during the cell cycle 6. Regulation of transcription by extracellular signals Section C: Systemic Regulation 7. Transcriptional regulation of early lymphocyte development 8. Transcriptional integration of hormone and metabolic signals by nuclear receptors 9. Developmental control by Hox transcriptional regulators and their cofactors 10. Tissue-specific regulation by transcription factors 11. Neural transcription factors 12. Abnormal transcription factors produced by chromosome translocations in human cancer