Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.
Editorial Foreword. Introduction. Bone Grafting Evolution. Materials. Ceramics. Polymers. Composites. Currently available grafts on the market. Growth Factors. BMP-2 and BMP-7. Other growth factors and delivery mechanisms. DBM and grafts. Cells and Biologics. Cell sources for orthopaedic defects. Cell sources for craniofacial defects. Animal Models for regeneration. Infection and antibiotics. Clinical Perspective. Orthopaedic Trauma. Spinal reconstruction. Dental and craniofacial reconstruction. Regulatory and ease-of-use