This book presents an up-to-date review of the mechanisms and regulation of translation in eukaryotes. Topics covered include the basic biochemical reactions of translation initiation, elongation and termination, and the regulation of these reactions under different physiological conditions and in virus-infected cells. The book belongs on the shelf of everyone interested in translation in eukaryotes, including students and researchers requiring comprehensive overviews of most aspects of translation and instructors who want to cover these topics at an advanced level.
Mechanism of Translation: Eukaryotic Ribosomes: Structure, Function, Biogenesis, and Evolution (I.G. Wool). Transfer RNAs and Aminoacyl-tRNA Synthetases (J. Lapointe and R. Giegé). mRNA and mRNP (J. Bag). Initiation: Met-tRNA Binding (H.O. Voorma). Initiation: mRNA and 60s Subunit Binding (R.E. Rhoads). Polypeptide Chain Elongation (L.I. Slobin). Peptide Chain Termination (R.P.C. Valle and A.-L. Haenni). Regulation of Translation: Binding of Met-tRNA (R.J. Jackson). Covalent Modification of Translational Components (M. Hümbelin and G. Thomas). Examples of Eukaryotic Translational Control: GCN4 and Ferritin (A. Hinnebusch and R.D. Klausner). The Translation of Picornaviruses (K. meerovitch, N. Sonenberg, and J. Pelletier). Adjustment of Translation to Special Physiological Conditions (V.M. Pain and M.J. Clemens). Regulation of Elongation Rate (A.S. Spirin and A.G. Ryazanov). Appendix: Comparison of Prokaryotic and Eukaryotic Translation (J.W.B. Hershey). Inhibitors of Eukaryotic Protein Synthesis (J.P.G. Ballesta). Nomenclature of Initiation, Elongation and Termination Factors for Translation in Eukaryotes (B. Safer). References. Index.