Viral Hemorrhagic Fevers (Hardback) book cover

Viral Hemorrhagic Fevers

Edited by Sunit K. Singh, Daniel Ruzek

© 2013 – CRC Press

596 pages | 16 Color Illus. | 69 B/W Illus.

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Hardback: 9781439884294
pub: 2013-07-18
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pub: 2016-04-19
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Viral hemorrhagic fevers have captured the imagination of the public and made their way into popular books and movies by virtue of their extreme virulence and mysterious origins. Since 2001, concerns have grown about the potential use of many hemorrhagic fever viruses as biological weapons. This has led to a resurgence in research to develop improved diagnostics, vaccines, and therapeutics—both for biodefense purposes and to treat naturally exposed persons. Written by international experts, Viral Hemorrhagic Fevers represents a major contribution to the virological literature and updates the state of knowledge of these dangerous illnesses.

Topics include:

  • A historical perspective and information on pathogenesis and immune responses
  • Animal models, which are critical to the development of vaccines and therapeutics
  • The roles of high-containment facilities and specially trained scientists in research
  • Prevention and control, including diagnostics and vaccine development
  • Old World Lassa and Lujo viruses and the New World Junin and Machupo viruses
  • Guanarito viruses and their cellular receptors
  • Bunyaviruses, including Rift Valley Fever, Crimean– Congo hemorrhagic fever, and hantaviruses that cause hemorrhagic fever with renal syndrome
  • The Ebola and Marburg filoviruses
  • Flaviviruses, including dengue fever, yellow fever, Kyanasur Forest, Alkhurma, and Omsk hemorrhagic fever viruses and other flaviviruses with hemorrhagic potential

Virologists, clinicians, biomedical researchers, microbiologists, and others needing a rapid overview of the nature of these illnesses will find this book an essential resource on clinical and basic science aspects of many viral hemorrhagic fevers. The book will also provide researchers with a springboard to further inquiry in combating what has become a major global threat.


"There is a definite need for a comprehensive consolidation of material on VHF viruses, especially in light of an elevated level of concern globally for emerging and re-emerging infectious diseases. This book fills that need. Although I have a few concerns about the overall quality of the writing in a few chapters, I can appreciate that styles may differ given the number of contributing authors. I would not consider the book to be a 'rapid overview' as the editors describe it, but a comprehensive and rather complex textbook. As a result, the audience may be limited to advanced practice clinicians and more seasoned researchers. Weighted numerical score: 80 - 3 stars."

—Sharon Medcalf, Ph.D, University of Nebraska Medical Center, Omaha, USA, from Doody's Book Reviews™

Table of Contents

General Aspects

Viral Hemorrhagic Fevers: History and Definitions; Jens H. Kuhn, Anna N. Clawson, Sheli R. Radoshitzky, Victoria Wahl-Jensen,

Sina Bavari, and Peter B. Jahrling

General Disease Pathology in Filoviral and Arenaviral Infections; Louis M. Huzella, Jennifer A. Cann, Matthew Lackemeyer, Victoria Wahl-Jensen, Peter B. Jahrling, Jens H. Kuhn, and Donna L. Perry

Interaction of the Host Immune System with Hemorrhagic Fever Viruses; Gavin C. Bowick

Vascular Endothelium and Hemorrhagic Fever Viruses; Nadine A. Dalrymple, Elena Gorbunova, Irina Gavrilovskaya, and Erich R. Mackow

Vascular Endothelial Dysfunctions: Viral Attack and Immunological Defense; Jayashree Apurupa Lahoti, Ritu Mishra, and Sunit Kumar Singh

Animal Models of Viral Hemorrhagic Fevers; Amy C. Shurtleff, Travis K. Warren, Derek Morrow, Sheli R. Radoshitzky, Jens H. Kuhn, and Sina Bavari

Role of Rodents and Bats in Human Viral Hemorrhagic Fevers; Victoria Wahl-Jensen, Sheli R. Radoshitzky, Fabian de Kok-Mercado,

Shannon L. Taylor, Sina Bavari, Peter B. Jahrling, and Jens H. Kuhn

Biosafety Issues and Clinical Management of Hemorrhagic Fever Virus Infections; George F. Risi and Thomas Arminio

BSL4 Workforce Preparedness in Hemorrhagic Fever Outbreaks; Sean G. Kaufman

Major Strategies for Prevention and Control of the Viral Hemorrhagic Fevers; Matthew L. Boulton and Eden V. Wells

Practical Considerations for Collection and Transportation

of Hemorrhagic Fever Samples; Manfred Weidmann and Mandy Elschner

Laboratory Diagnosis of Viral Hemorrhagic Fevers; Miroslav Fajfr and Daniel Růžek

Vaccine Research Efforts for Hemorrhagic Fever Viruses; Shannon S. Martin and Mary Kate Hart

Specific Infections

Pathogenic Old World Arenaviruses; Jason Botten, Benjamin King, Joseph Klaus, and Christopher Ziegler

Lassa Fever; Daniel G. Bausch, Lina M. Moses, Augustine Goba, Donald S. Grant, and Humarr Khan

Lujo Virus Hemorrhagic Fever; Janusz T. Paweska, Petrus Jansen van Vuren, and Jacqueline Weyer

Receptor Determinants of Zoonosis and Pathogenesis of New World Hemorrhagic Fever Arenaviruses; Stephanie Jemielity, Michael Farzan, and Hyeryun Choe

Argentine Hemorrhagic Fever; Víctor Romanowski, Matías L. Pidre, M. Leticia Ferrelli, Cecilia Bender, and Ricardo M. Gómez

Bolivian Hemorrhagic Fever; Sheli R. Radoshitzky, Fabian de Kok-Mercado, Peter B. Jahrling, Sina Bavari, and Jens H. Kuhn

"Venezuelan" Hemorrhagic Fever; Sheli R. Radoshitzky, Fabian de Kok-Mercado, Peter B. Jahrling, Sina Bavari, and Jens H. Kuhn

Rift Valley Fever Virus and Hemorrhagic Fever; Alexander N. Freiberg and Ramon Flick

Crimean–Congo Hemorrhagic Fever Virus; Onder Ergonul

Hemorrhagic Fever with Renal Syndrome; Paul Heyman, Tatjana Avsic-Zupanc, Christel Cochez, Ana Saksida, and Ake Lundkvist

Ebola virus Infection; Anthony Griffiths, Andrew Hayhurst, Robert Davey, Olena Shtanko, Ricardo Carrion Jr., and Jean L. Patterson

Marburg Virus Disease; Steven B. Bradfute, Sina Bavari, Peter B. Jahrling, and Jens H. Kuhn

Dengue Hemorrhagic Fever; Chwan-Chuen King and Guey Chuen Perng

Yellow Fever Virus Infection; Kate D. Ryman and William B. Klimstra

Kyasanur Forest Disease; Gerhard Dobler and Frank Hufert

Alkhurma Virus Hemorrhagic Fever; Ziad A. Memish, Shamsudeen Fagbo, and Ali Zaki

Omsk Hemorrhagic Fever; Daniel Růžek, Valeriy V. Yakimenko, Lyudmila S. Karan, and Sergey E. Tkachev


About the Editors

Dr. Sunit K. Singh is a scientist and leads a research group in the area of neurovirology and inflammation biology at the prestigious Centre for Cellular and Molecular Biology, Hyderabad, India. His main areas of research interest are emerging and re-emerging viral infections, neurovirology, inflammation biology, and immunology. Dr. Singh has received several awards, including the Skinner Memorial Award, Travel Grant Awards, NIH-Fogarty Fellowship, and Young Scientist Award. He is associated with several international journals of repute as an associate editor and editorial board member.

Dr. Daniel Ružek is a head of the Department of Virology and head of the Research Group on Emerging Viral Infections at the Veterinary Research Institute, Brno, Czech Republic; a research scientist at the Institute of Parasitology, Academy of Sciences of the Czech Republic; and an assistant professor in the University of South Bohemia, Ceské Budejovice, Czech Republic. His primary field is virology with a research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Omsk hemorrhagic fever virus, dengue virus, and West Nile virus. In 2009, he was awarded the prestigious international Sinnecker–Kunz Award for young researchers.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Infectious Diseases
MEDICAL / Veterinary Medicine / General
SCIENCE / Life Sciences / Neuroscience