Virulence Mechanisms of Bacterial Pathogens: 5th Edition (Hardback) book cover

Virulence Mechanisms of Bacterial Pathogens

5th Edition

Edited by Indira T. Kudva, Nancy A. Cornick, Paul Plummer, Qijing Zhang, Tracy Nicholson, John P. Bannantine

ASM Press

871 pages

Purchasing Options:$ = USD
Hardback: 9781555819279
pub: 2016-07-26

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Ground-breaking overview of an enduring topic

Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies.

A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including

• how metabolism shapes the host-pathogen interface

• interactions across species and genera

• mechanisms of the secretion systems

• evasion, survival, and persistence mechanisms

• new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens

Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.


“This new edition of Virulence Mechanisms of Bacterial Pathogens is edited by renowned experts in the field, and encompasses state-of-the-art review articles and critical overviews. From bacterial:host interactions and communication to bacterial secretion systems, persistence, and novel targeted therapies, this is a ‘MUST READ’ for anyone studying bacterial infectious agents.”

Carolyn Hovde Bohach, Ph.D., University Distinguished Professor, University of Idaho School of Food Science; Director, NIH Idaho INBRE Program;

President, National Association of IDeA Principal Investigators (NAIPI)

Table of Contents

Contributors ix

Preface xv

Acknowledgments xvii


Section Editor: Nancy A. Cornick

1 Evolution of Bacterial Pathogens Within the Human Host 3

Kimberly A. Bliven and Anthony T. Maurelli

2 Bacterial Metabolism Shapes the Host–Pathogen Interface 15

Karla D. Passalacqua, Marie-Eve Charbonneau, and Mary X.D. O’Riordan

3 Iron Acquisition Strategies of Bacterial Pathogens 43

Jessica R. Sheldon, Holly A. Laakso, and David E. Heinrichs


Section Editor: Paul J. Plummer

4 Sociomicrobiology and Pathogenic Bacteria 89

Joao B. Xavier

5 Candida-Bacteria Interactions: Their Impact on Human Disease 103

Devon L. Allison, Hubertine M. E. Willems, J.A.M.S. Jayatilake, Vincent M. Bruno,

Brian M. Peters, and Mark E. Shirtliff

6 Microbial Endocrinology in the Pathogenesis of Infectious Disease 137

Mark Lyte

7 Small RNAs in Bacterial Virulence and Communication 169

Sarah L. Svensson and Cynthia M. Sharma


Section Editor: Indira T. Kudva

8 Bacterial Secretion Systems: An Overview 215

Erin R. Green and Joan Mecsas

9 The Structure and Function of Type III Secretion Systems 241

Ryan Q. Notti and C. Erec Stebbins

10 Mechanism and Function of Type IV Secretion During Infection

of the Human Host 265

Christian Gonzalez-Rivera, Minny Bhatty, and Peter J. Christie

11 Type V Secretion Systems in Bacteria 305

Enguo Fan, Nandini Chauhan, D. B. R. K. Gupta Udatha,

Jack C. Leo, and Dirk Linke

12 The Versatile Type VI Secretion System 337

Christopher J. Alteri and Harry L.T. Mobley

13 Type VII Secretion: A Highly Versatile Secretion System 357

Louis S. Ates, Edith N. G. Houben, and Wilbert Bitter


Section Editor: Qijing Zhang

14 Stress Responses, Adaptation, and Virulence of Bacterial Pathogens

During Host Gastrointestinal Colonization 387

Annika Flint, James Butcher, and Alain Stintzi

15 Bacterial Evasion of Host Antimicrobial Peptide Defenses 413

Jason N. Cole and Victor Nizet

16 Antigenic Variation in Bacterial Pathogens 445

Guy H. Palmer, Troy Bankhead, and H. Steven Seifert

17 Mechanisms of Antibiotic Resistance 481

Jose M. Munita and Cesar A. Arias


Section Editor: Tracy L. Nicholson

18 Chronic Bacterial Pathogens: Mechanisms of Persistence 515

Mariana X. Byndloss and Renee M. Tsolis

19 The Staphylococcal Biofilm: Adhesins, Regulation,

and Host Response 529

Alexandra E. Paharik and Alexander R. Horswill

20 Surviving Between Hosts: Sporulation and Transmission 567

Michelle C. Swick, Theresa M. Koehler, and Adam Driks

21 Staying Alive: Vibrio cholerae’s Cycle of Environmental Survival,

Transmission, and Dissemination 593

Jenna G. Conner, Jennifer K. Teschler, Christopher J. Jones,

and Fitnat H. Yildiz


Section Editor: John P. Bannantine

22 Hijacking and Use of Host Lipids by Intracellular Pathogens 637

Alvaro Toledo and Jorge L. Benach

23 Contrasting Lifestyles Within the Host Cell 667

Elizabeth Di Russo Case and James E. Samuel

24 Intracellular Growth of Bacterial Pathogens: The Role of Secreted

Effector Proteins in the Control of Phagocytosed Microorganisms 693

Valérie Poirier and Yossef Av-Gay

25 Cellular Exit Strategies of Intracellular Bacteria 715

Kevin Hybiske and Richard Stephens


Section Editor: Bryan H. Bellaire

26 Novel Targets of Antimicrobial Therapies 741

Sarah E. Maddocks

27 Innovative Solutions to Sticky Situations: Antiadhesive Strategies for

Treating Bacterial Infections 753

Zachary T. Cusumano, Roger D. Klein, and Scott J. Hultgren

28 The Role of Biotin in Bacterial Physiology and Virulence: a Novel

Antibiotic Target for Mycobacterium tuberculosis 797

Wanisa Salaemae, Grant W. Booker, and Steven W. Polyak

29 Recent Advances and Understanding of Using Probiotic-Based

Interventions to Restore Homeostasis of the Microbiome for the

Prevention/Therapy of Bacterial Diseases 823

Jan S. Suchodolski and Albert E. Jergens

Index 843

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Biology / Microbiology