This book provides researchers and practitioners with a unique collection of current research on the role of vitamins and micronutrients in cancer prevention and treatment. New theories are discussed, including a hypothesis that dietary factors may protect against genetically predisposed cancers. Mechanisms by which different vitamins and minerals appear to inhibit carcinogenesis or cell transformation are described, including vitamins A, C, E, and selenium protection against oxidative stress by induction of enzymes as catalase and dismutase or inteference with free radical mechanisms; organosulfur compound inhibition of P450 activation enzymes or enhancement of detoxification enzymes; metal ion effects in the modulation of gene expression by site-specific binding of Zn-finger loop domains; B-carotene metabolite up-regulation of gap junctional communication between cells; and vitamin D3 elimination of amplified oncogenes or drug resistant genes. The book also reviews literature implicating a possible relationship between potassium and the control of cancer. Other information presented includes a discussion of contemporary technologies and data associating lipotrope deficiencies with alterations in xenobiotic metabolism, nucleic acid methylation, purine and pyrimidine synthesis, signal transduction, and chromosome anomalies.
Table of Contents
1. Epidemiologic Linkage: Diet, Genetics, and Cancer 2.Vitamin B6 and Other Inhibitors of Glucocorticoid Receptor Function and Cell Death of B16 Melanoma Cells 3. Cancer Chemoprevention by Retinoids and Carotenoids: Proposed Role of Gap Junctional Communication 4. The Role of Free Radicals and Dietary Antioxidants in Cellular and Molecular Carcinogenesis in Vitro 5. An Intervention Trial on Precursor Lesions for Oesophageal Cancer in a High Incidence Area of China 6. Chemoprevention of Gastrointestinal Cancer in Animals by Naturally Occurring Organosulfur Compounds in Allium Vegetables 7. Genotoxicity of Ni2+ in Xenopus: Search for the Molecular Mechanisms 8. Rationale and Possible Mechanisms by which Selenium Inhibits Mammary Cancer 9. Caloric Restriction and Cancer: Search for Molecular Mechanisms 10. Choline, Methionine, Folate and Chemical Carcinogenesis 11. Effects of Folic Acid Deficiency on Tumor Cell Biology 12. Recent Studies on the Neoplasia and Abnormal Cellular Differentiation in Methyl Insufficiency 13. Optimal Detection of and Effect of Vitamin D3 on Extrachomosomal Oncogene Sequences 14. Anti-Tumor Proliferation Properties of Vitamin E 15. Vitamin E Effects on Avian Retrovirus-Induced Immune Dysfunctions 16. Relationships Between Potassium and Cancer